Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism

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dc.creatorSandro Soares Almeida
dc.creatorFlávia Campos Corgosinho
dc.creatorCarlos EN Amorim
dc.creatorMarcos Fernandes Gregnani
dc.creatorRaquel Munhoz da Silveira Campos
dc.creatorDeborah Cristina Landi Masquio
dc.creatorPriscila de Lima Sanches
dc.creatorAline de Piano Ganen
dc.creatorJoão Bosco Pesquero
dc.creatorAna Raimunda Dâmaso
dc.creatorMarco Tulio de Mello
dc.creatorSergio Tufik
dc.creatorRonaldo Carvalho Araújo
dc.date.accessioned2024-02-16T16:54:10Z
dc.date.accessioned2025-09-09T00:35:05Z
dc.date.available2024-02-16T16:54:10Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.identifier.doihttps://doi.org/10.1177/1470320317703451
dc.identifier.issn1752-8976
dc.identifier.urihttps://hdl.handle.net/1843/64075
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of the Renin-Angiotensin-Aldosterone System
dc.rightsAcesso Aberto
dc.subjectSíndrome metabólica
dc.subjectObesidade
dc.subjectEnzima conversora da angiotensina
dc.subjectPolimorfismo genético
dc.subject.otherInterdisciplinary therapy
dc.subject.otherMetabolic syndrome
dc.subject.otherObesity
dc.subject.otherAngiotensin-converting enzyme
dc.subject.otherPolymorphism
dc.titleDifferent metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism
dc.typeArtigo de periódico
local.citation.issue2
local.citation.volume18
local.description.resumoIntroduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents.Methods: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Genomic DNA was extracted from circulating leukocytes.Results: Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Regarding lipid profile, subjects with ID and DD genotypes from both groups reduced their low-density lipoprotein cholesterol levels significantly. The metabolic parameters from the ID and DD genotypes of the non-metabolic syndrome group showed a significantly improved insulin response.Conclusion: In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. In addition, the I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly. These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy.
local.identifier.orcidhttps://orcid.org/0000-0002-4392-0953
local.identifier.orcidhttps://orcid.org/0000-0002-8684-7290
local.identifier.orcidhttps://orcid.org/0000-0002-6169-745X
local.identifier.orcidhttps://orcid.org/0000-0003-0187-6402
local.identifier.orcidhttps://orcid.org/0000-0001-6433-0816
local.identifier.orcidhttps://orcid.org/0000-0002-4507-632X
local.identifier.orcidhttps://orcid.org/0000-0001-7675-7470
local.identifier.orcidhttps://orcid.org/0000-0003-3896-2208
local.identifier.orcidhttps://orcid.org/0000-0003-0095-4608
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE ESPORTES
local.publisher.initialsUFMG
local.url.externahttps://journals.sagepub.com/doi/10.1177/1470320317703451

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