Immunohistochemical analysis of FOXP3+ regulatory t cells in lower lip squamous cell carcinomas

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dc.creatorFernando Antonio Portelada Cunha Filho
dc.creatorMaria Cassia Ferreira de Aguiar
dc.creatorLélia Batista de Souza
dc.creatorLeão Pereira Pinto
dc.creatorGustavo Pina Godoy
dc.creatorPollianna Muniz Alves
dc.creatorCassiano Francisco Weege Nonaka
dc.date.accessioned2024-07-30T19:35:02Z
dc.date.accessioned2025-09-08T23:00:05Z
dc.date.available2024-07-30T19:35:02Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1807-3107BOR-2016.vol30.0130
dc.identifier.issn18073107
dc.identifier.urihttps://hdl.handle.net/1843/72116
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Oral Research
dc.subjectEpithelial cells
dc.subjectLip
dc.subjectCarcinoma
dc.subjectT-lymphocytes
dc.subjectImmunohistochemistry
dc.subjectCarcinogenesis
dc.subjectNeoplasms
dc.subjectLymphatic metastasis
dc.subjectInflammation
dc.subject.otheroral squamous cell carcinoma
dc.subject.otherlip acesso aberto Immunohistochemical analysis of FOXP3+ regulatory t cells in lower lip squamous cell carcinomas busca dia 29/07/2024 fao clinica assunto carcinoma
dc.subject.otherimmunohistochemistry
dc.subject.otherlymphocites
dc.titleImmunohistochemical analysis of FOXP3+ regulatory t cells in lower lip squamous cell carcinomas
dc.typeArtigo de periódico
local.citation.epage8
local.citation.issue1
local.citation.spage1
local.citation.volume30
local.description.resumoThe aim of this study was to determine the number of FoxP3+ regulatory T (Treg) cells in the microenvironment of lower lip squamous cell carcinomas (LLSCCs) and to correlate the findings with clinicopathological parameters (tumor size/extent, regional lymph node metastasis, clinical stage, and histopathological grade of malignancy). Fifty cases of LLSCC were selected. Lymphocytes exhibiting nuclear immunostaining for FoxP3 were quantified in 10 microscopic fields at the deep invasive front of LLSCCs. The results were analyzed statistically using the nonparametric Mann-Whitney test and Fisher's exact test. FoxP3+ lymphocytes were observed in all cases studied. The number of these cells tended to be higher in smaller tumors, tumors without regional lymph node metastasis, and tumors in early clinical stages, but the difference was not statistically significant (p > 0.05). Low-grade tumors contained a larger number of FoxP3+ lymphocytes than high-grade tumors (p = 0.019). Tumors with an intense inflammatory infiltrate exhibited a larger number of Treg cells (p = 0.035). On the other hand, the number of FoxP3+ lymphocytes was smaller in tumors arranged in small cell clusters (p = 0.003). No significant differences in the number of FoxP3+ lymphocytes were observed according to the degree of keratinization (p = 0.525) or nuclear pleomorphism (p = 0.343). The results suggest the participation of Treg cells in immune and inflammatory responses in the microenvironment of LLSCCs. These cells may play a more important role in early stages rather than in advanced stages of lip carcinogenesis.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bor/a/GYhL3Y5BhT7gSjV5DwkPyvn/?lang=en

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