Effect of photobiomodulation therapy on reducing the chemo-induced oral mucositis severity and on salivary levels of CXCL8/interleukin 8, nitrite, and myeloperoxidase in patients undergoing hematopoietic stem cell transplantation: a randomized clinical trial

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dc.creatorDaniella Ribeiro Naves Salvador
dc.creatorAline Carvalho Batista
dc.creatorDanilo Figueiredo Soave
dc.creatorNancy Tomoko Sacono
dc.creatorEduardo Fernandes de Castro
dc.creatorGeisa Badauy Lauria Silva
dc.creatorLarissa Pereira e Silva
dc.creatorTarcília Aparecida da Silva
dc.creatorMarize Campos Valadares
dc.creatorElismauro Francisco Mendonça
dc.date.accessioned2025-04-01T15:32:40Z
dc.date.accessioned2025-09-08T22:58:34Z
dc.date.available2025-04-01T15:32:40Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s10103-017-2263-1
dc.identifier.issn1435-604X
dc.identifier.urihttps://hdl.handle.net/1843/81166
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofLasers in Medical Science
dc.rightsAcesso Restrito
dc.subjectInterleukin-8
dc.subjectHematopoietic stem cell transplantation
dc.subjectInflammation
dc.subjectLaser therapy
dc.subjectMucositis
dc.subjectLow-level light therapy
dc.subjectSaliva
dc.subjectEvaluation study
dc.subjectColorimetry
dc.subjectNitrites
dc.subjectPeroxidase
dc.subjectStomatitis
dc.subject.otherCXCL8
dc.subject.otherHematopoietic stem cell transplantation
dc.subject.otherLaser therapy
dc.subject.otherInflammation
dc.subject.otherMucositis
dc.subject.otherPhotobiomodulation therapy.
dc.titleEffect of photobiomodulation therapy on reducing the chemo-induced oral mucositis severity and on salivary levels of CXCL8/interleukin 8, nitrite, and myeloperoxidase in patients undergoing hematopoietic stem cell transplantation: a randomized clinical trial
dc.typeArtigo de periódico
local.citation.epage1810
local.citation.spage1801
local.citation.volume32
local.description.resumoOral mucositis (OM) is the most common debilitating complication among patients undergoing hematopoietic stem cell transplantation (HSCT). Photobiomodulation therapy (PBM) has shown beneficial effects in the treatment of OM, but few studies have evaluated its biological effects. This study evaluated the effect of PBM on the reduction of OM severity in patients undergoing HSCT and its relation to the modulation of the inflammatory response. Fifty-one patients were randomly assigned to two groups: PBM [submitted to PBM from admission (AD) to D+7] (n = 27) and control (n = 24) [received oral hygiene]. OM severity was assessed daily using the WHO scale. Saliva samples were collected on AD, D+7, and hospital discharge (HD) to measure CXCL8/interleukin 8, using cytometric bead array analysis and nitrite (NO) and myeloperoxidase (MPO) using colorimetric methods. PBM significantly reduced the severity of OM from D+7 to D+11 (p < 0.05). All non-interventional patients (controls) who developed grade 2 or higher OM induced an increase of CXCL8 in saliva (n = 14) on D+7. PBM led to a decrease in CXCL8 on D+7 in 85% of patients, while 70.8% of patients in the control group presented an increase in this chemokine (p = 0.007). NO decreased from AD to D+7 in the PBM group (p > 0.05). MPO significantly decreased on D+7 in both groups (p < 0.05). PBM brought about a reduction in the severity of OM in patients undergoing HSCT, and this reduction was associated with a decrease in CXCL8 salivary levels.
local.identifier.orcidhttps://orcid.org/0000-0002-2117-5593
local.identifier.orcidhttps://orcid.org/0000-0001-9782-3940
local.identifier.orcidhttps://orcid.org/0000-0002-4514-3588
local.identifier.orcidhttps://orcid.org/0000-0003-2185-7129
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0002-0379-1325
local.identifier.orcidhttps://orcid.org/0000-0002-6751-3279
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s10103-017-2263-1

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