A New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus

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dc.creatorGabriel F. Dossantos
dc.creatorJacqueline Aparecida Takahashi
dc.date.accessioned2023-10-09T23:21:32Z
dc.date.accessioned2025-09-09T00:30:08Z
dc.date.available2023-10-09T23:21:32Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/0001-3765201720170240
dc.identifier.issn0001-3765
dc.identifier.urihttps://hdl.handle.net/1843/59347
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAcademia Brasileira de Ciências
dc.rightsAcesso Aberto
dc.subjectBiotransformação (Metabolismo)
dc.subjectInibidores
dc.subjectQuímica
dc.subject.otherAcetylcholinesterase inhibitors
dc.subject.otherBiotransformation
dc.subject.otherGreen glycosylation
dc.subject.otherMucor plumbeus
dc.subject.otherTrachyloban-19-oic acid
dc.titleA New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus
dc.typeArtigo de periódico
local.citation.epage1969
local.citation.issue3
local.citation.spage1961
local.citation.volume86
local.description.resumoThe in vitro metabolism of a widespread natural product, trachyloban-19-oic acid (1), by the fungal species Mucor plumbeus was studied in a sucrose-yeast liquid medium. Two products were isolated, and their structures were determined by spectroscopic means as 7β-hydroxytrachyloban-19-oic acid (5) and trachyloban-19-O-β-D-glucopyranosyl ester (6). To the best of our knowledge, compound 6 is herein reported by the first time in the literature. These compounds were assayed for acetylcholinesterase inhibition along with some related compounds. Compound 6 showed the highest acetylcholinesterase inhibitory activity at 10000 µg/mL among the tested compounds, a result (92.89%) comparable to the activity of the positive control, galanthamine (94.21%). Therefore, biotransformation of the natural product 1 by M. plumbeus produced a novel compound with potential as a new lead to develop anti-Alzheimer medicines.
local.identifier.orcidhttps://orcid.org/0000-0002-8831-1609
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/aabc/a/sWrhpW3MQ8pYtkPDHpq58sK/?lang=en

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