Motor learning and COMT Val158met polymorphism: analyses of oculomotor behavior and corticocortical communication

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dc.creatorNathálya Gardênia de Holanda Marinho Nogueira
dc.creatorGuilherme Menezes Lage
dc.creatorDébora Marques de Miranda
dc.creatorMaicon Rodrigues Albuquerque
dc.creatorBárbara de Paula Ferreira
dc.creatorMarco Túlio Silva Batista
dc.creatorJuliana Otoni Parma
dc.creatorTércio Apolinário-Souza
dc.creatorLucas Eduardo Antunes Bicalho
dc.creatorHerbert Ugrinowitsch
dc.date.accessioned2024-08-05T20:44:52Z
dc.date.accessioned2025-09-09T00:33:28Z
dc.date.available2024-08-05T20:44:52Z
dc.date.issued2020
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.nlm.2020.107157
dc.identifier.issn1074-7427
dc.identifier.urihttps://hdl.handle.net/1843/72664
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNeurobiology of Learning and Memory
dc.rightsAcesso Restrito
dc.subjectAprendizagem motora
dc.subjectCapacidade motora
dc.subjectPolimorfismo (Genética)
dc.titleMotor learning and COMT Val158met polymorphism: analyses of oculomotor behavior and corticocortical communication
dc.typeArtigo de periódico
local.citation.epage10
local.citation.spage1
local.citation.volume168
local.description.resumoDifferences in motor learning can be partially explained by differences in genotype. The catechol-O-methyltransferase (COMT) Val158Met polymorphism regulates the dopamine (DA) availability in the prefrontal cortex modulating motor learning and performance. Given the differences in tonic and phasic DA transmission, this study aimed to investigate whether the greater cognitive flexibility associated with the Val allele would favor the learning of movement parametrization, while the greater cognitive stability associated with the Met allele favors the acquisition of the movement pattern. Furthermore, we investigated if the genotypic characteristics impact visual scanning of information related to parametrization and to the movement pattern, and the level of cortical connectivity associated with motor planning and control. Performance and learning of a sequential motor task were compared among three genotypes (Val/Val, Val/Met, and Met/Met), as well as their oculomotor behavior and level of cortical coherence. The findings show that the cognitive flexibility promoted by the Val allele is associated with a better parametrization. The search for information through visual scanning was specific to each genotype. Also, a greater cortical connectivity associated with the Val allele was found. The combined study of behavioral, electrophysiological and molecular levels of analysis showed that the cognitive stability and flexibility associated with the COMT alleles, influence specific aspects of motor learning.
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1074742720300010

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