A PDGFRα-Mediated switch toward CD9ʰᶦᵍʰ adipocyte progenitors controls obesity-induced adipose tissue fibrosis

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dc.creatorGeneviève Marcelin
dc.creatorAdaliene Versiani Matos Ferreira
dc.creatorYuejun Liu
dc.creatorMichael Atlan
dc.creatorJudith Aron-Wisnewsky
dc.creatorVéronique Pelloux
dc.creatorYair Botbol
dc.creatorMarc Ambrosini
dc.creatorMagali Fradet
dc.creatorChristine Rouault
dc.creatorCorneliu Hénégar
dc.creatorJean-Sébastien Hulot
dc.creatorChristine Poitou
dc.creatorAdriana Torcivia
dc.creatorRaphael Nail-Barthelemy
dc.creatorJean-Christophe Bichet
dc.creatorEmmanuel L. Gautier
dc.creatorKarine Clément
dc.date.accessioned2023-05-24T19:37:06Z
dc.date.accessioned2025-09-08T23:50:50Z
dc.date.available2023-05-24T19:37:06Z
dc.date.issued2017
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.cmet.2017.01.010
dc.identifier.issn1932-7420
dc.identifier.urihttps://hdl.handle.net/1843/53891
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCell Metabolism
dc.rightsAcesso Aberto
dc.subjectTecido adiposo branco
dc.subjectObesidade
dc.subjectFibrose
dc.subject.otherWhite adipose tissue
dc.subject.otherObesity
dc.subject.otherFibrosis
dc.titleA PDGFRα-Mediated switch toward CD9ʰᶦᵍʰ adipocyte progenitors controls obesity-induced adipose tissue fibrosis
dc.typeArtigo de periódico
local.citation.epage685
local.citation.issue3
local.citation.spage673
local.citation.volume25
local.description.resumoObesity-induced white adipose tissue (WAT) fibrosis is believed to accelerate WAT dysfunction. However, the cellular origin of WAT fibrosis remains unclear. Here, we show that adipocyte platelet-derived growth factor receptor-a-positive (PDGFRa+) progenitors adopt a fibrogenic phenotype in obese mice prone to visceral WAT fibrosis. More specifically, a subset of PDGFRa+ cells with high CD9 expression (CD9high) originates pro-fibrotic cells whereas their CD9low counterparts, committed to adipogenesis, are almost completely lost in the fibrotic WAT. PDGFRa pathway activation promotes a phenotypic shift toward PDGFRa+ CD9high fibrogenic cells, driving pathological remodeling and altering WAT function in obesity. These findings translated to human obesity as the frequency of CD9high progenitors in omental WAT (oWAT) correlates with oWAT fibrosis level, insulin-resistance severity, and type 2 diabetes. Collectively, our data demonstrate that in addition to representing a WAT adipogenic niche, different PDGFRa+ cell subsets modulate obesity-induced WAT fibrogenesis and are associated with loss of metabolic fitness.
local.identifier.orcidhttps://orcid.org/0000-0002-9779-5529
local.identifier.orcidhttps://orcid.org/0000-0003-2256-8652
local.identifier.orcidhttps://orcid.org/0000-0002-8486-5591
local.identifier.orcidhttps://orcid.org/0000-0001-5463-6117
local.identifier.orcidhttps://orcid.org/0000-0003-2976-7566
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1550413117300451?via%3Dihub

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