Body mass index and the visceral adipose tissue expression of IL-6 and TNF-alpha are associated with the morphological severity of non-alcoholic fatty liver disease in individuals with class III obesity

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dc.creatorAntônio Sérgio Barcala Jorge
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorAlanna Fernandes Paraíso
dc.creatorGislaine Cândida Batista Jorge
dc.creatorChristine Mendes Silveira
dc.creatorLudmilla Regina de Souza
dc.creatorErivelton Pereira Santos
dc.creatorAndré Luiz Sena Guimarães
dc.creatorSergio Henrique Sousa Santos
dc.creatorAlfredo Mauricio Batista de Paula
dc.date.accessioned2022-08-17T13:06:48Z
dc.date.accessioned2025-09-08T23:34:33Z
dc.date.available2022-08-17T13:06:48Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.orcp.2016.03.009
dc.identifier.issn1871-403X
dc.identifier.urihttps://hdl.handle.net/1843/44304
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofObesity Research & Clinical Practice
dc.rightsAcesso Aberto
dc.subjectÍndice de massa corporal
dc.subjectTecido adiposo
dc.subjectObesidade
dc.subjectFígado - Doenças
dc.subjectCitocinas
dc.titleBody mass index and the visceral adipose tissue expression of IL-6 and TNF-alpha are associated with the morphological severity of non-alcoholic fatty liver disease in individuals with class III obesity
dc.typeArtigo de periódico
local.citation.epage8
local.citation.issue1
local.citation.spage1
local.citation.volume12
local.description.resumoObjectives: to analyze the mRNA expression of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) in the liver and white adipose tissue samples of individuals with class III obesity (body mass index ≥40.0 kg/m2) with non-alcoholic fatty liver disease (NAFLD). Methods: this cross-sectional study included patients with class III obesity exhibiting early or late morphological presentation of NAFLD (non-alcoholic hepatic steatosis [NAFL], n = 8 and non-alcoholic steatohepatitis [NASH], n = 13, respectively). All patients underwent bariatric surgery and peripheral blood, liver, and visceral white adipose tissue (WAT) samples were collected. Socio-demographic, anthropometric, clinical, plasma biochemical, and nutritional characteristics of each study subject were assessed and compared between patients presenting with NAFL and NASH. IL-6 and TNF-α mRNA expression in the liver and WAT samples were measured by using quantitative real time-polymerase chain reaction (qRT-PCR). Results: individuals with class III obesity and NASH showed higher body mass index (BMI) and higher IL-6 and TNF-α mRNA expression in the WAT compared to that of patients with NAFL (p = 0.01, for all associations). Conclusions: individuals with class III obesity with higher morphological severity of NAFLD exhibited higher BMI and higher IL-6 and TNF-α expression in the WAT. Future prospective studies are warranted to determine how BMI, IL-6, and TNF-α affect the progression of NAFLD in individuals with class III obesity.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1871403X16300060?via%3Dihub

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