2-phthalimidethanol and 2-phthalimidethyl nitrate inhibit mechanical allodynia, neutrophil recruitment and cytokine and chemokine production in a murine model of articular inflammation

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dc.creatorAdriana Martins Godin
dc.creatorÂngelo de Fátima
dc.creatorMárcio de Matos Coelho
dc.creatorRenes de Resende Machado
dc.creatorDébora Pereira Araújo
dc.creatorRaquel Rezende Menezes
dc.creatorAna Mercy Siebra de Brito
dc.creatorIvo Souza Ferraz de Melo
dc.creatorGiovanna Maria Elias Coura
dc.creatorLeandro Francisco Silva Bastos
dc.creatorFlávio Almeida Amaral
dc.creatorMauro Martins Teixeira
dc.date.accessioned2024-09-10T19:53:45Z
dc.date.accessioned2025-09-09T00:25:40Z
dc.date.available2024-09-10T19:53:45Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.pharep.2017.01.033
dc.identifier.issn1734-1140
dc.identifier.urihttps://hdl.handle.net/1843/76258
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPharmacological Reports
dc.rightsAcesso Restrito
dc.subjectAgentes antiinflamatórios
dc.subjectAnalgésicos
dc.subjectInflamação
dc.subjectAgentes antineoplásicos
dc.subject.otherPhthalimide
dc.subject.other2-phthalimidethyl nitrate (PTD-NO)
dc.subject.otherMechanical allodynia
dc.subject.otherCytokine
dc.subject.otherChemokine
dc.subject.otherArticular inflammation
dc.title2-phthalimidethanol and 2-phthalimidethyl nitrate inhibit mechanical allodynia, neutrophil recruitment and cytokine and chemokine production in a murine model of articular inflammation
dc.typeArtigo de periódico
local.citation.epage695
local.citation.issue4
local.citation.spage691
local.citation.volume69
local.description.resumoBackground: Phthalimide analogs have been shown to exhibit anti-inflammatory, analgesic and immunomodulatory activities in different preclinical assays. This study aimed to investigate the potential role of 2-phthalimidethanol (PTD-OH) and 2-phthalimidethyl nitrate (PTD-NO) in a murine model of antigen-induced articular inflammation. Methods: Articular inflammation was induced by intra-articular injection of methylated bovine serum albumin (mBSA) in the knee joint of immunized male C57BL/6J mice. The animals were pre-treated with PTD-OH or PTD-NO (500 mg/kg, per os, – 1 h). Nociceptive threshold was measured using an electronic von Frey apparatus. The total number of leukocytes in the synovial cavity was determined. Concentrations of tumor necrosis factor (TNF)-α and CXCL-1 and myeloperoxidase (MPO) activity were determined in periarticular tissue. Results: Both PTD-OH and PTD-NO inhibited at similar extent the mechanical allodynia, neutrophil recruitment to the synovial cavity and periarticular tissue and TNF-α and CXCL-1 production induced by intra-articular challenge with mBSA in immunized mice. Conclusions: PTD-OH and PTD-NO exhibit a marked activity in a murine model of antigen-induced articular inflammation in immunized animals. These results reinforce the interest in the investigation of phthalimide analogs devoid of the glutarimide ring as candidates to analgesic and anti-inflammatory drugs.
local.identifier.orcidhttps://orcid.org/0000-0002-1284-1195
local.identifier.orcidhttps://orcid.org/0000-0002-4857-2302
local.identifier.orcidhttps://orcid.org/0000-0002-1695-0612
local.identifier.orcidhttps://orcid.org/0000-0002-6944-3008
local.identifier.orcidhttps://orcid.org/0000-0003-2344-5590
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S173411401630144X

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