SIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma

Página do item simplificado
dc.creatorCamila Santos Pereira
dc.creatorMarcos Vinícius Macedo de Oliveira
dc.creatorLudmilla Regina de Souza
dc.creatorOtávio Cardoso Filho
dc.creatorValéria Couto Quintão
dc.creatorAndréia Brito de Souza
dc.creatorMarcos Vinícius Mendes Barroso
dc.creatorLuiz Henrique da Silveira
dc.creatorAndré Luiz Sena Guimarães
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2023-03-08T11:59:49Z
dc.date.accessioned2025-09-09T00:13:55Z
dc.date.available2023-03-08T11:59:49Z
dc.date.issued2019-07
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.22161/ijaers.6712
dc.identifier.issn2456-1908
dc.identifier.urihttps://hdl.handle.net/1843/50729
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Advanced Engineering Research and Science (IJAERS)
dc.rightsAcesso Aberto
dc.subjectPele - Câncer
dc.subjectMelanoma
dc.subjectNevo
dc.titleSIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma
dc.typeArtigo de periódico
local.citation.epage98
local.citation.issue7
local.citation.spage90
local.citation.volume6
local.description.resumoThe current study evaluated the proliferation index and immunohistochemical expression of SIRT1 on normal skin and cutaneous melanocytic nevi (CMN) and cutaneous malignant melanoma (CMM). Formalin-fixed paraffin-embedded tissue samples from 43 CMN, 22 CMM and 10 normal skin were obtained and clinical data were abstracted from the electronic medicalrecord.SIRT1 and Ki67 proteins expressions were evaluated regarding to clinic pathological behavior in CMM. The level of significance was set at α = 5% (p < 0.05).Our findings showed that SIRT1 positivity was significantly higher in benign melanocytic nevi than that in cutaneous malignant melanoma (p=0.002). As expected, the proliferation index was significantly higher in samples of cutaneous malignant melanoma as compared to the normal skin and melanocytic nevi (p=0.001). However, the expression of Ki67 protein was not also significantly related to the expression of SIRT1 (p > 0.05). In conclusion, low expression of SIRT1 and high proliferation index may play an important role in progression of cutaneous melanoma.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://ijaers.com/detail/sirt1-and-ki67-immunohistochemical-expression-in-progression-of-cutaneous-malignant-melanoma/

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
SIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma.pdf
Tamanho:
275.98 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG