Prognostic value of left ventricular longitudinal strain by speckle-tracking echocardiography in patients with sickle cell disease

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dc.creatorMaria Betânia Solis Resende
dc.creatorMaria do Carmo Pereira Nunes
dc.creatorTeresa Cristina a Ferrari
dc.creatorChristiano g Araújo
dc.creatorMaria Carmen m. Vasconcelos
dc.creatorJulia Teixeira Tupinambás
dc.creatorRebeca Coeli Teodoro Maciel Dias
dc.creatorFlavio Coelho Barros
dc.creatorJosé Nélio Januário
dc.creatorMárcia Melo Barbosa
dc.date.accessioned2023-06-27T20:13:55Z
dc.date.accessioned2025-09-08T23:04:06Z
dc.date.available2023-06-27T20:13:55Z
dc.date.issued2020-07-03
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s10554-020-01924-3
dc.identifier.issn15695794
dc.identifier.urihttps://hdl.handle.net/1843/55441
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofThe International Journal of Cardiovascular Imaging
dc.rightsAcesso Restrito
dc.subjectAnemia Falciforme
dc.subjectDeformação Longitudinal Global
dc.subjectResultado do Tratamento
dc.subject.otherSickle cell disease
dc.subject.otherSpeckle-tracking echocardiography
dc.subject.otherleft ventricular longitudinal strain
dc.subject.otherclinical outcome
dc.titlePrognostic value of left ventricular longitudinal strain by speckle-tracking echocardiography in patients with sickle cell disease
dc.typeArtigo de periódico
local.citation.epage2153
local.citation.spage2145
local.citation.volume36
local.description.resumoCardiovascular complications have been increasingly detected in patients with sickle cell disease (SCD). Two-dimensional speckle-tracking echocardiography (STE) detects early myocardial changes in a number of pathophysiological processes, which may be useful in SCD. This study was designed to examine the value of STE in predicting clinical outcome in adult patients with SCD. A total of 219 patients, mean age 33±12 years were prospectively enrolled. Several clinical, laboratory and echocardiographic variables including left ventricular global longitudinal strain (LVGLS) by STE were assessed. The endpoint was a composite of the following events: (1) all-cause mortality, (2) three or more acute painful episodes that require hospitalization in one year, (3) acute chest syndrome and (4) hospitalization due to disease complication. The majority of the patients had enlargement of LV and left atrial (LA) with preserved ejection fraction. During the mean follow-up of 30 months, 69 patients (32%) had reached the endpoint, including eight deaths (3.7%). No diference was observed in the parameters of diastolic function comparing the patients with and without events. LVGLS ranged from −12.25 to−25.44 (mean−20.26±2.5), with higher values in the patients who had events compared with those who did not. In the multivari able analysis, higher LVGLS values were associated with adverse events (adjusted OR 1.25; 95% CI 1.04–1.51; p=0.021), independently of the TR maximal velocity and LV ejection fraction. In patients with SCD, higher LV global longitudinal strain was a predictor of adverse outcome, independently of age, TR velocity and LV function.
local.identifier.orcidhttps://orcid.org/0000-0002-0912-3782
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s10554-020-01924-3

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