Influence of COMT Val158Met polymorphism on emotional decision-making: a sex-dependent relationship?

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dc.creatorDanielle de Souza Costa
dc.creatorAntoine Bechara
dc.creatorJonas Jardim de Paula
dc.creatorMarco Aurélio Romano-Silva
dc.creatorHumberto Corrêa da Silva Filho
dc.creatorGuilherme Menezes Lage
dc.creatorDébora Marques de Miranda
dc.creatorLeandro Fernandes Malloy-Diniz
dc.date.accessioned2024-08-01T21:55:36Z
dc.date.accessioned2025-09-09T00:07:23Z
dc.date.available2024-08-01T21:55:36Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.psychres.2016.10.073
dc.identifier.issn0165-1781
dc.identifier.urihttps://hdl.handle.net/1843/72280
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPsychiatry Research
dc.rightsAcesso Restrito
dc.subjectNeuropsicologia
dc.subjectGenética molecular
dc.subjectSexo
dc.titleInfluence of COMT Val158Met polymorphism on emotional decision-making: a sex-dependent relationship?
dc.typeArtigo de periódico
local.citation.epage655
local.citation.spage650
local.citation.volume246
local.description.resumoThe biological underpinnings of sex-related differences in decision-making are still under-explored. The COMT gene is related to sexual dimorphism and with different choices made under uncertainty, albeit no study has specifically investigated a moderation effect of sex on the association between the COMT gene and the performance on decision-making paradigms. In this study, we investigated the influence of the COMT Val158Met polymorphism on Iowa Gambling Task (IGT) performance depending on sex in a healthy adult sample. Participants were 192 healthy adults (84 men and 108 women). The first 40 choices in the IGT were considered decisions under ambiguity and the last 60 choices decisions under risk. To test our moderation hypothesis we used a separate regressions approach. The results revealed a sex-dependent effect of COMT Va l 158Met polymorphism on decision-making as measured by the IGT. Val/Val women showed the best performance in the last trials of the IGT. Therefore, the COMT Val158Met polymorphism may be considered a genetic marker underlying sex differences in decision-making.
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0165178116300312

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