Obesity and malnutrition similarly alter the renin-angiotensin system and inflammation in mice and human adipose

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dc.creatorThales de Almeida Pinheiro
dc.creatorAntônio Sérgio Barcala Jorge
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorThaisa de Almeida Pinheiro
dc.creatorEmíllio César Neves Ferreira
dc.creatorThaisa Soares Crespo
dc.creatorGislaine Cândida Batista-Jorge
dc.creatorCássio André Vieira
dc.creatorDeborah de Farias Lelis
dc.creatorAlanna Fernandes Paraíso
dc.creatorUgo Borges Pinheiro
dc.creatorMariane Bertagnolli
dc.creatorCarlos Juliano Brant Albuquerque
dc.creatorAndré Luiz Sena Guimarães
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAntônio Prates Caldeira
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2022-08-18T14:15:16Z
dc.date.accessioned2025-09-09T00:11:44Z
dc.date.available2022-08-18T14:15:16Z
dc.date.issued2017-10
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1016/j.jnutbio.2017.06.008
dc.identifier.issn0955-2863
dc.identifier.urihttps://hdl.handle.net/1843/44360
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofThe Journal of Nutritional Biochemistry
dc.rightsAcesso Aberto
dc.subjectObesidade
dc.subjectDesnutrição
dc.subjectDieta de baixa caloria
dc.subjectSistema renina-angiotensina
dc.subjectTecido adiposo
dc.subjectDistúrbios alimentares
dc.titleObesity and malnutrition similarly alter the renin-angiotensin system and inflammation in mice and human adipose
dc.typeArtigo de periódico
local.citation.epage82
local.citation.spage74
local.citation.volume48
local.description.resumoThe main goal of the present study was to evaluate the metabolic profile, inflammatory markers and the gene expression of the renin–angiotensin system (RAS) components in the visceral adipose tissue of eutrophic, obese and malnourished individuals and mice models of obesity and food restriction. Male Swiss mice were divided into eight groups and fed different levels of food restriction (20%, 40%, or 60%) using standard or high-fat diet. Metabolic profile and adipose tissues were assessed. The expression of AGT (Angiotensinogen), ACE (Angiotensin-converting enzyme), ACE2 (Angiotensin-converting enzyme 2), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in the mice epididymal adipose tissue and the human visceral adipose tissue was assessed. The main findings showed reduced body weight, improved metabolism, decreased adipose tissues weight and reduced adipocyte area in mice submitted to food restriction. Diminished expression of IL-6, TNF-α, AGT, AT1 and ACE was detected in the 20% and 40% food restriction animal groups, although they were increased in the 60% malnourished group. Increased expression of IL-6, TNF-α, AGT and ACE in obese and malnourished individuals was observed. Adipocytes size was increased in obese individuals and reduced in malnutrition. In conclusion, we found that food restriction of 20% and 40% improved the metabolic profile, ameliorated the inflammatory status and down-regulated the RAS in mice. Severe 60% food restriction (malnutrition), however, stimulated a proinflammatory state and increased AGT and ACE expression in the adipose tissue of mice. A similar profile was observed in the adipose tissue of obese and malnourished humans, supporting the critical role of inflammation and RAS as mediators of metabolic disorders.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0955286317302413?via%3Dihub

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