Intrarater and interrater agreement and reliability of vestibular evoked myogenic potential triggered by galvanic vestibular stimulation (galvanic-VEMP) for HTLV-1 associated myelopathy testing

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dc.creatorJúlia Fonseca de Morais Caporali
dc.creatorLudimila Labanca
dc.creatorKyonis Rodrigues Florentino
dc.creatorBárbara Oliveira Souza
dc.creatorDenise Utsch Gonçalves
dc.date.accessioned2023-08-09T21:07:23Z
dc.date.accessioned2025-09-09T00:04:35Z
dc.date.available2023-08-09T21:07:23Z
dc.date.issued2018
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0204449
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1843/57667
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPLOS ONE
dc.rightsAcesso Aberto
dc.subjectInfecções por HTLV-I
dc.subject.otherHTLV-1
dc.subject.otherHAM/TSP
dc.subject.otherTeste de função vestibular
dc.titleIntrarater and interrater agreement and reliability of vestibular evoked myogenic potential triggered by galvanic vestibular stimulation (galvanic-VEMP) for HTLV-1 associated myelopathy testing
dc.typeArtigo de periódico
local.citation.epage13
local.citation.issue9
local.citation.spage1
local.citation.volume13
local.description.resumoBackground:The vestibular evoked myogenic potential triggered by galvanic vestibular stimulation (galvanic-VEMP) has been used to assess the function of the vestibulospinal motor tract and is a candidate biomarker to predict and monitor the human T-cell lymphotropic virus type 1(HTLV-1) associated myelopathy (HAM). This study determined the agreement and reliability of this exam.Methods: Galvanic-VEMP was performed in 96 participants, of which 24 patients presented HAM, 27 HTLV-1-asymptomatic carriers, and 45 HTLV-1-negative asymptomatic controls. Galvanic vestibular stimulation was achieved by passing a binaural and bipolar current at a 2 milliam peres (mA) intensity for 400 milliseconds (ms) between the mastoid processes. Galvanic VEMP electromyographic wave responses of short latency (SL) and medium latency (ML) were recorded from the gastrocnemius muscle. Intrarater (test-retest) and interrater (two independent examiners) agreement and reliability were assessed by standard error of measurement (SEM), coefficient of repeatability (CR), intraclass correlation coefficient (ICC), and Kappa coefficient. Results:In the total sample (n = 96), SL and ML medians were 56 ms (IQR 52–66) and 120 ms (IQR 107–130), respectively. The intrarater repeatability measures for SL and ML were, respectively: SEM of 6 and 8 ms; CR of 16 and 22 ms; ICC of 0.80 (p<0.001) and 0.91 (p<0.001); and a Kappa coefficient of 0.53 (p<0.001) and 0.82 (p<0.001). The interrater reproducibility measures for SL and ML were, respectively: SEM of 3 and 10 ms; CR of 8 and 27 ms; ICC of 0.95 (p<0.001) and 0.86 (p<0.001); and a Kappa coefficient of 0.77 (p<0.001) and 0.88 (p<0.001). Conclusion Galvanic-VEMP is a reliable and reproducible method to define the integrity of the vestibulospinal tract. Longitudinal studies will clarify its validity in the clinical context, aimed at achieving an early diagnosis and the monitoring of HAM.
local.identifier.orcidhttps://orcid.org/0000-0003-3296-4800
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204449

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