Mycotoxin deactivator improves performance, antioxidant status, and reduces oxidative stress in nursery pigs fed diets containing mycotoxins

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dc.creatorErika Vivian Santos
dc.creatorRodrigo Lima Domingos
dc.creatorIdael Mateus Goes Lopes
dc.creatorLis Lorena Melúcio Guedes
dc.creatorValesca Ribeiro Lima
dc.creatorLarissa Alves Cardoso
dc.creatorBruno Alexander Nunes Silva
dc.creatorDalton de Oliveira Fontes
dc.creatorMara da Silveira Benfato
dc.creatorFernanda Schäfer Hackenhaar
dc.creatorTiago Salomon
dc.creatorDavid Vani Jacob
dc.creatorDamien Prévéraud
dc.creatorWagner Azis Garcia Araujo
dc.creatorEduardo Maria da Glória
dc.date.accessioned2023-10-30T14:56:54Z
dc.date.accessioned2025-09-09T00:20:34Z
dc.date.available2023-10-30T14:56:54Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.1093/jas/skab329
dc.identifier.issn1525-3163
dc.identifier.urihttps://hdl.handle.net/1843/60232
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Animal Science
dc.rightsAcesso Restrito
dc.subjectSuíno -- Criação
dc.subjectNutrição animal
dc.subjectAlimentação e rações
dc.subjectSuíno -- Desempenho
dc.subjectToxicologia
dc.titleMycotoxin deactivator improves performance, antioxidant status, and reduces oxidative stress in nursery pigs fed diets containing mycotoxins
dc.typeArtigo de periódico
local.citation.epage5652
local.citation.issue10
local.citation.spage5647
local.citation.volume99
local.description.resumoIngestion of mycotoxins can result in many problems, including decreased growth rates and immune suppression. The present study aimed to evaluate the impact of the supplementation of a mycotoxin deactivator composed by adsorbent clay minerals; inactivated fermentation extracts of Saccharomyces cerevisiae; and blend of antioxidants, organic acids, and botanicals in diets containing added mycotoxins for nursery pigs on their performance and antioxidant status. Ninety pigs weaned with 24 d of age (7.12 ± 0.68 kg of BW) were used. Pigs were housed in pens of three animals each according to body weight, litter origin, and sex. The dietary treatments consisted of feeding the pigs with a standard control diet as negative control (NC; mycotoxin levels at accepted regulatory Brazilian Ministry of Agriculture standards; deoxynivalenol (DON): <100 μg/kg; zearalenone (ZEA): <20 μg/kg; fumonisins (FB): <1 mg/kg); the standard diet added with mycotoxins to reach a low contamination level is considered as positive low (PCL−; DON: 900 μg/kg; ZEA: 100 μg/kg; FB: 5,000 μg/kg) without deactivator; a positive low added the deactivator at an inclusion rate of 1 kg/ton (PCL+); the standard diet added with mycotoxins to reach a high contamination level is considered as positive high (PCH−; DON: 4,500 μg/kg; ZEA: 500 μg/kg; FB: 18,000 μg/kg) without the deactivator; and a positive high added the deactivator at an inclusion rate of 5 kg/ton (PCH+). Pigs were individually weighed at the beginning and at the end of each phase and feed intake recorded based on daily pen intake during the experiment. On days 7, 19, 34, and 43 post-weaning, blood samples were drawn for antioxidant analyses. Antioxidant enzymes (glutathione peroxidase [GPx] and total superoxide dismutase [TSOD]), vitamins [Vit A, E, and C], and malondialdehyde [MDA]) were evaluated in erythrocyte and plasma samples. Pigs challenged with mycotoxins presented lower performance traits, decrease in the efficiency of central antioxidant systems (↓GPx, ↓TSOD, ↓Vit A, ↓Vit E, and ↓Vit C), and a higher oxidative damage to lipids (↑MDA) when compared with the control and deactivator-associated treatments. Our findings showed that the use of a mycotoxin deactivator can mitigate the negative impacts on performance and oxidative stress when animals are subjected to diets contaminated by different levels of mycotoxins.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/jas/article-abstract/99/10/skab277/6380201

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