Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic review

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dc.creatorRafael Coelho Magalhães
dc.creatorLetícia Pereira Pimenta
dc.creatorIzabela Guimarães Barbosa
dc.creatorJanaina Matos Moreira
dc.creatorJoão Luís Vieira Monteiro de Barros
dc.creatorAntonio Lucio Teixeira
dc.creatorAna Cristina Simões e Silva
dc.date.accessioned2022-04-08T14:47:50Z
dc.date.accessioned2025-09-08T22:53:45Z
dc.date.available2022-04-08T14:47:50Z
dc.date.issued2018-04
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.ijdevneu.2017.10.006
dc.identifier.issn1873-474X
dc.identifier.urihttps://hdl.handle.net/1843/40931
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Developmental Neuroscience
dc.rightsAcesso Aberto
dc.subjectInflamação
dc.subjectCitocinas
dc.subjectDesempenho psicomotor
dc.subjectDesenvolvimento cognitivo
dc.subjectPrematuros
dc.subject.otherInflammation
dc.subject.otherCytokines
dc.subject.otherNeurotrophic factors
dc.subject.otherMotor development
dc.subject.otherCognitive development
dc.subject.otherPreterm
dc.titleInflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic review
dc.typeArtigo de periódico
local.citation.epage37
local.citation.spage29
local.citation.volume65
local.description.resumoTo provide a systematic review investigating the role of inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates. Data Source: Databases including PubMed, BIREME, and Scopus were systematically searched. Observational studies, as well as transversal, and cohort studies using human subjects published from 1990 to September 2017 were eligible for inclusion. Two authors independently identified eligible studies and analyzed their characteristics, quality, and accuracy in depth. Data synthesis: 11 eligible studies clearly investigated the association between peripheral inflammation and motor and/or cognitive development in preterm infants. However, the selected populations differed in relation to the events associated with prematurity and the risk factors to abnormal motor and/or cognitive development. These studies measured circulating levels of cytokines, chemokines, adhesion molecules, acute phase proteins, and growth factors. The most commonly analyzed proteins were IL-1β, IL-6, TNF, CCL5/RANTES, CXCL8/IL-8, IGFBP-1, and VEGF. In seven of the eligible studies, plasma levels of IL-6 correlated with development delay. Two studies reported correlation between CXCL8/IL-8 plasma levels with cognitive and motor delay. In one study, higher levels of MCP-1/CCL2 were associated with better cognitive and motor outcome. Conclusion: There is preliminary evidence indicating that circulating inflammatory molecules are associated with motor and cognitive development in preterm neonates, even considering different populations.
local.identifier.orcidhttp://orcid.org/0000-0002-8960-2256
local.identifier.orcidhttps://orcid.org/ 0000-0003-0074-3034
local.identifier.orcidhttps://orcid.org/ 0000-0002-9621-5422
local.identifier.orcidhttps://orcid.org/0000-0001-9222-3882
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE TERAPIA OCUPACIONAL
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1016/j.ijdevneu.2017.10.006

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