Physicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples

Página do item simplificado
dc.creatorLuciana Flávia de Almeida Romani
dc.creatorMaria Irene Yoshida
dc.creatorElionai Cassiana de Lima Gomes
dc.creatorRenes de Resende Machado
dc.creatorFelipe Fernandes Rodrigues
dc.creatorMárcio de Matos Coelho
dc.creatorMarcelo Antônio de Oliveira
dc.creatorMaria Betânia de Freitas-Marques
dc.creatorRosane Aguiar da Silva San Gil
dc.creatorWagner da Nova Mussel
dc.date.accessioned2022-03-30T20:07:51Z
dc.date.accessioned2025-09-08T23:38:37Z
dc.date.available2022-03-30T20:07:51Z
dc.date.issued2018-04
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.jpha.2017.12.006
dc.identifier.issn20951779
dc.identifier.urihttps://hdl.handle.net/1843/40631
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Pharmaceutical Analysis
dc.rightsAcesso Aberto
dc.subjectQuímica
dc.subjectFarmácia de manipulação
dc.subjectFarmácia
dc.subject.otherMeloxicam
dc.subject.otherPolymorphism
dc.subject.otherHirshfeld surface
dc.subject.otherAnti-inflammatory activity
dc.titlePhysicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples
dc.typeArtigo de periódico
local.citation.epage108
local.citation.issue2
local.citation.spage103
local.citation.volume8
local.description.resumoMeloxicam (MLX) is an anti-inflammatory drug susceptible to variations and crystalline transitions. In compounding pharmacies, the complete crystallographic evaluation of the raw material is not a routine procedure. We performed a complete crystallographic characterization of aleatory raw MLX samples from compounding pharmacies. X-ray diffraction indicated the presence of two crystalline forms in one sample. DSC experiments suggested that crystallization, or a crystal transition, occurred differently between samples. The FTIR and 1H NMR spectra showed characteristic assignments. 13C solid-state NMR spectroscopy indicated the presence of more than one phase in a sample from pharmacy B. The Hirshfeld surface analysis, with electrostatic potential projection, allowed complete assignment of the UV spectra in ethanol solution. The polymorph I of meloxicam was more active than polymorph III in an experimental model of acute inflammation in mice. Our results highlighted the need for complete crystallographic characterization and the separation of freely used raw materials in compounding pharmacies, as a routine procedure, to ensure the desired dose/effect.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2095177917301399

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Physicochemical characterization, the Hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples.pdf
Tamanho:
1.54 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG