Cutaneous application of capsaicin cream reduces clinical signs of experimental colitis and repairs intestinal barrier integrity by modulating the gut microbiota and tight junction proteins

Página do item simplificado
dc.creatorElandia Aparecida dos Santos
dc.creatorJanayne Luihan Silva
dc.creatorPaola Caroline Lacerda Leocádio
dc.creatorMaria Emília Rabelo Andrade
dc.creatorCelso Martins Queiroz-Junior
dc.creatorNathan S. S. Oliveira
dc.creatorJuliana Leite Alves
dc.creatorJamil Silvano Oliveira
dc.creatorEdenil Costa Aguilar
dc.creatorKennedy Boujour
dc.creatorBruno Cogliati
dc.creatorValbert Nascimento Cardoso
dc.creatorSimone Odília Antunes Fernandes
dc.creatorAna Maria Caetano de Faria
dc.creatorJacqueline Isaura Alvarez Leite
dc.date.accessioned2025-09-05T22:38:07Z
dc.date.accessioned2025-09-09T01:07:01Z
dc.date.available2025-09-05T22:38:07Z
dc.date.issued2024
dc.format.mimetypepdf
dc.identifier.doi10.1021/acsptsci.4c00207
dc.identifier.issn25759108
dc.identifier.urihttps://hdl.handle.net/1843/84970
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Aberto
dc.subjectDoença inflamatória
dc.subject.otherColite ulcerativa
dc.subject.otherSulfato de dextrana
dc.subject.otherDoenças inflamatórias intestinais
dc.subject.otherCanais catiônicos
dc.subject.otherCapsaicina
dc.subject.otherTRPV
dc.titleCutaneous application of capsaicin cream reduces clinical signs of experimental colitis and repairs intestinal barrier integrity by modulating the gut microbiota and tight junction proteins
dc.typeArtigo de periódico
local.citation.epage2153
local.citation.spage2143
local.citation.volume7
local.description.resumoCapsaicin, a pungent compound in chili peppers, is described as having potent anti-inflammatory, antioxidant, and antimicrobial properties. It is also described as a potential modulator of the immune system and intestinal microbiota. Oral or rectal administration of capsaicin has been studied to treat or prevent colitis. However, those vias are often not well accepted due to the burning sensation that capsaicin can cause. Our objective was to evaluate whether the application of capsaicin skin creams (0.075%) would be effective in improving inflammation and epithelial barrier function as well as the composition of the gut microbiota in a model of mild colitis induced by dextran sulfate sodium (1.5%). The results showed that the cutaneous application of capsaicin reversed weight loss and decreased colon shortening and diarrhea, all typical signs of colitis. There was also an improvement in the intestinal epithelial barrier, preserving proteins from tight junctions. We also evaluated the biodistribution of 99mtechnetium-radiolabeled capsaicin (99mTc-CAPS) applied to the back skin of the animals. We found significant concentrations of 99 mTc-Cap in the colon and small intestine after 2 and 4 h of administration. In addition, there was an increased expression of capsaicin receptor TRPV1 in the colon. Moreover, animals with colitis receiving cutaneous capsaicin presented a better short-chain fatty acid profile and increased levels of SIgA, suggesting increased microbiota diversity. In conclusion, our work opens avenues for further studies to better understand capsaicin’s potential benefits and mechanisms in addressing colitis through cutaneous application.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://pmc.ncbi.nlm.nih.gov/articles/PMC11249629/

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Cutaneous Application of Capsaicin Cream Reduces Clinical Signs of Experimental Colitis and Repairs Intestinal Barrier Integrity by Modulating the Gut Microbiota and Tight Junction Proteins.pdf
Tamanho:
9.05 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG