Relevance of HLA-G, HLA-E and IL-10 expression in lip carcinogenesis

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dc.creatorAndréia Souza Gonçalves
dc.creatorJéssica Petini Oliveira
dc.creatorCarolina Ferrari Piloni Oliveira
dc.creatorTarcília Aparecida da Silva
dc.creatorElismauro Francisco Mendonça
dc.creatorIsabela Jubé Wastowski
dc.creatorAline Carvalho Batista
dc.date.accessioned2025-03-28T19:18:28Z
dc.date.accessioned2025-09-08T23:18:55Z
dc.date.available2025-03-28T19:18:28Z
dc.date.issued2016-09
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.humimm.2015.12.001
dc.identifier.issn1879-1166
dc.identifier.urihttps://hdl.handle.net/1843/81085
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHuman Immunology
dc.rightsAcesso Restrito
dc.subjectHLA-E antigens
dc.subjectHLA-G antigens
dc.subjectInterleukin-10
dc.subjectProteins
dc.subjectEvaluation study
dc.subjectCarcinoma, squamous cell
dc.subjectCheilitis
dc.subjectImmunohistochemistry
dc.subject.otherHLA-G
dc.subject.otherHLA-E
dc.subject.otherIL-10
dc.subject.otherLip carcinogenesis
dc.subject.otherPotentially malignant disorder
dc.titleRelevance of HLA-G, HLA-E and IL-10 expression in lip carcinogenesis
dc.typeArtigo de periódico
local.citation.epage790
local.citation.issue9
local.citation.spage785
local.citation.volume77
local.description.resumoHLA-G, HLA-E and IL-10 are molecules which can provide tumor immunosuppression as well as the capacity of evasion to the immune system host. This study set out to evaluate HLA-G, HLA-E and IL-10 expression in lip squamous cell carcinoma (LSCC) and in a potentially malignant disorder (actinic cheilitis - AC), correlating the expression of these proteins with the degree of epithelial dysplasia. Immunohistochemistry was undertaken to identify HLA-G, HLA-E and IL-10 in samples from patients with LSCC (n=20), AC (n=30) and healthy lip mucosa (control) (n=10). A semiquantitative scoring system was used for analysis. Differences between the groups were evaluated using the Pearson Chi-Squared test. The percentage of LSCC samples showing high immunoreactivity (IRS>2) for HLA-G, HLA-E and IL-10 (neoplastic/epithelial cells) and HLA-E (stroma/connective tissue) was significantly higher that of the control (P<0.05). A tendency for a progressive increase in the proteins analyzed was observed from the control to AC and to LSCC. The degree of dysplasia in the AC samples was not significantly associated with the proteins evaluated (P>0.05). The high expression of HLA-G, HLA-E and IL-10 in AC and LSCC reflects the capacity that these pathologies have for evasion and progression.
local.identifier.orcidhttps://orcid.org/0000-0003-1787-3521
local.identifier.orcidhttps://orcid.org/0000-0003-0760-7334
local.identifier.orcidhttps://orcid.org/0000-0001-6341-4479
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0002-6751-3279
local.identifier.orcidhttps://orcid.org/0000-0001-5441-4186
local.identifier.orcidhttps://orcid.org/0000-0002-2117-5593
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0198885915005819?via%3Dihub

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