Synthesis, Fungitoxic Activity against Botrytis cinerea and Phytotoxicity of Alkoxyclovanols and Alkoxyisocaryolanols

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dc.creatorAdrianade Almeida Pinto Bracarense
dc.creatorRosa Durán-patrón
dc.creatorAntonio J. Macías-sánchez
dc.creatorJociani Ascari
dc.creatorGiovanni Gontijo de Souza
dc.creatorThays Silva Oliveira
dc.creatorAntonio Ruano-gonzález
dc.creatorAna A. Pinto
dc.creatorMaria Amélia Diamantino Boaventura
dc.creatorJacqueline Aparecida Takahashi
dc.creatorIsidro G. Collado
dc.date.accessioned2023-10-18T20:53:36Z
dc.date.accessioned2025-09-08T23:29:04Z
dc.date.available2023-10-18T20:53:36Z
dc.date.issued2021-12-15
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/jof7121079
dc.identifier.issn2309-608X
dc.identifier.urihttps://hdl.handle.net/1843/59657
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Fungi
dc.rightsAcesso Aberto
dc.subjectQuímica
dc.subjectFungos
dc.subjectAtividade antifúngica
dc.subject.otherBotrytis cinerea
dc.subject.otherAntifungal
dc.subject.otherPhytotoxic activity
dc.subject.otherClovane
dc.subject.otherIsocaryolane
dc.subject.otherLactuca sativa
dc.titleSynthesis, Fungitoxic Activity against Botrytis cinerea and Phytotoxicity of Alkoxyclovanols and Alkoxyisocaryolanols
dc.typeArtigo de periódico
local.citation.epage17
local.citation.issue12
local.citation.spage1079
local.citation.volume7
local.description.resumoClovane and isocaryolane derivatives have been proven to show several levels of activity against the phytopathogenic fungus Botrytis cinerea. Both classes of sesquiterpenes are reminiscent of biosynthetic intermediates of botrydial, a virulence factor of B. cinerea. Further development of both classes of antifungal agent requires exploration of the structure–activity relationships for the antifungal effects on B. cinerea and phytotoxic effects on a model crop. In this paper, we report on the preparation of a series of alkoxy-clovane and -isocaryolane derivatives, some of them described here for the first time (2b, 2d, 2f–2h, and 4c–4e); the evaluation of their antifungal properties against B. cinerea, and their phytotoxic activites on the germination of seeds and the growth of radicles and shoots of Lactuca sativa (lettuce). Both classes of compound show a correlation of antifungal activity with the nature of side chains, with the best activity against B. cinerea for 2d, 2h, 4c and 4d. In general terms, while 2-alkoxyclovan-9-ols (2a–2e) exert a general phytotoxic effect, this is not the case for 2-arylalkoxyclovan-9-ols (2f–2i) and 8-alkoxyisocaryolan-9-ols (4a–4d), where stimulating effects would make them suitable candidates for application to plants
local.identifier.orcidhttps://orcid.org/0000-0002-7928-9921
local.identifier.orcidhttps://orcid.org/0000-0001-8190-6127
local.identifier.orcidhttps://orcid.org/0000-0002-8831-1609
local.identifier.orcidhttps://orcid.org/0000-0002-8612-0593
local.identifier.orcidhttps://orcid.org/0000-0002-5307-4164
local.identifier.orcidhttps://orcid.org/0000-0001-6002-4977
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2309-608X/7/12/1079

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