Spinal cord hypometabolism associated with infection by human T-cell lymphotropic virus type 1(HTLV-1)

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dc.creatorLuiz Claudio Romanelli
dc.creatorMarco Aurelio Romano Silva
dc.creatorRodrigo Nicolato
dc.creatorDébora M. Miranda
dc.creatorAnna Barbara Carneiro Proietti
dc.creatorMarcelo Mamede
dc.creatorHérika Vasconcelos
dc.creatorMarina Martins
dc.creatorAnísia S. D. Ferreira
dc.creatorDaniela Rosa
dc.creatorJonas de Paula
dc.date.accessioned2023-07-19T16:49:23Z
dc.date.accessioned2025-09-09T00:04:06Z
dc.date.available2023-07-19T16:49:23Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0006720
dc.identifier.issn1935-2735
dc.identifier.urihttps://hdl.handle.net/1843/56691
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPLOS Neglected Tropical Diseases
dc.rightsAcesso Aberto
dc.subjectEndemias - Brasil
dc.subjectHTLV-I (Virus)
dc.subject.otherHTLV-1
dc.subject.otherInfection is endemic
dc.titleSpinal cord hypometabolism associated with infection by human T-cell lymphotropic virus type 1(HTLV-1)
dc.typeArtigo de periódico
local.citation.epage19
local.citation.issue8
local.citation.spage1
local.citation.volume12
local.description.resumoBackground HTLV-1 infection is endemic in Brazil. About 1 to 2% of the Brazilian population is estimated to be infected, but most infected HTLV-1 individuals do not know about their own infection, which favors the continuity of sexual and vertical virus transmission. In addition, HTLV-1 associated central nervous system diseases and their pathophysiologic mechanisms are not fully understood. This study aimed to evaluate the correlation of spinal cord metabolism, viral and inflammatory profiles with features of neurological presentation in HTLV-1 infected individuals. Methodology This is a cross-sectional study of a cohort including 48 HTLV-1 infected individuals clinically classified as asymptomatic-AG (N = 21), symptomatic-SG (N = 11) and HAM/TSP-HG (N = 16) and a nested case-control study with HTLV-1 infected individuals-HIG (N = 48) and HTLV-1 non infected controls-CG (N = 30) that had their spinal cord analysed by Positron Emission Tomography with 18F-Fluordeoxyglucose (18F-FDG PET/CT). HTLV-1 infected individuals had 18F-FDG PET/CT results analyzed with clinical and demographic data, proviral load, cytokines and chemokines in the blood and cerebrospinal fluid (CSF). Principal Findings 18F-FDG PET/CT showed hypometabolism in the thoracic spinal cord in HTLV-1 infected individuals. The method had an accuracy of 94.4% to identify HAM/TSP. A greater involvement of the thoracic spinal cord was observed, although hypometabolism was also observed in the cervical spinal cord segment in HTLV-1 infected individuals. Individuals with HAM/TSP showed a pro-inflammatory profile in comparison to asymptomatic and symptomatic groups, with a higher level of Interferon-inducible T-cell alpha chemoattractant (ITAC/CXCL11), IL-6, IL-12p70 in the plasma; and ITAC, IL-4, IL-5, IL-8 (CXCL8) and TNF-alpha in the CSF. Using regression, thoracic spinal cord SUV (standardized uptake value) and CSF ITAC level were identified as the HAM/TSP predictors in the multivariate model. Conclusions 18F-FDG PET/CT imaging showed spinal cord hypometabolism in most HTLV-1 infected individuals, even in the asymptomatic HTLV-1 group. Thoracic spinal cord hypometabolism and CSF-ITAC levels were identified predictors of HAM/TSP.
local.identifier.orcidhttps://orcid.org/0000-0002-7936-0687
local.identifier.orcidhttps://orcid.org/0000-0002-6558-4639
local.identifier.orcidhttps://orcid.org/0000-0003-1585-7720
local.identifier.orcidhttps://orcid.org/0000-0002-7081-8401
local.identifier.orcidhttps://orcid.org/0000-0003-4302-5817
local.identifier.orcidhttps://orcid.org/0000-0001-5818-0954
local.identifier.orcidhttps://orcid.org/0000-0002-6292-1716
local.identifier.orcidhttps://orcid.org/0000-0003-2506-8450
local.identifier.orcidhttps://orcid.org/0000-0001-8868-7895
local.identifier.orcidhttps://orcid.org/0000-0001-5530-2346
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA E IMAGEM
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006720

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