Synthesis, characterization and radiolabeling of polymeric nano-micelles as a platform for tumor delivering

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dc.creatorCaroline Mari Ramos Oda
dc.creatorRenata Salgado Fernandes
dc.creatorSávia Caldeira de Araújo Lopes
dc.creatorMônica Cristina de Oliveira
dc.creatorValbert Nascimento Cardoso
dc.creatorDaniel Moreira dos Santos
dc.creatorAdriano Monteiro de Castro Pimenta
dc.creatorÂngelo Malachias de Souza
dc.creatorRogério Magalhães Paniago
dc.creatorDanyelle M. Townsend
dc.creatorPatrick M. Colletti
dc.creatorDomenico Rubello
dc.creatorRicardo José Alves
dc.creatorAndré Luís Branco de Barros
dc.creatorElaine Amaral Leite
dc.date.accessioned2023-04-28T17:33:17Z
dc.date.accessioned2025-09-09T00:34:16Z
dc.date.available2023-04-28T17:33:17Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2017.01.144
dc.identifier.issn1950-6007
dc.identifier.urihttps://hdl.handle.net/1843/52667
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Restrito
dc.subjectSíntese
dc.subjectTumores
dc.subjectNanopartículas
dc.subject.otherPolymeric micelles
dc.subject.otherSynthesis
dc.subject.otherRadiolabeling
dc.subject.otherPlatform for tumor delivering
dc.titleSynthesis, characterization and radiolabeling of polymeric nano-micelles as a platform for tumor delivering
dc.typeArtigo de periódico
local.citation.epage275
local.citation.spage268
local.citation.volume89
local.description.resumoThe use of nanoparticles for diagnostic approaches leads to higher accumulation in the targeting tissue promoting a better signal-to-noise ratio and consequently, early tumor detection through scintigraphic techniques. Such approaches have inherent advantages, including the possibility of association with a variety of gamma-emitting radionuclides available, among them, Tecnethium–99 m (99mTc). 99mTc is readily conjugated with nanoparticles using chelating agents, such as diethylenetriaminepentaacetic acid (DTPA). Leveraging this approach, we synthesized polymeric micelles (PM) consisting of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-2000] (DSPE-mPEG2000) functionalized with DTPA for radiolabeling with 99mTc. Micelles made up of DSPE-mPEG2000 and DSPE-PEG2000-DTPA had a mean diameter of  ∼10 nm, as measured by DLS and SAXS techniques, and a zeta potential of −2.7 ± 1.1 mV. Radiolabeled micelles exhibited high radiochemical yields and stability. In vivo assays indicated long blood circulation time (456.3 min). High uptake in liver, spleen and kidneys was observed in the biodistribution and imaging studies on healthy and tumor-bearing mice. In addition, a high tumor-to-muscle ratio was detected, which increased over time, showing accumulation of the PM in the tumor region. These findings indicate that this system is a promising platform for simultaneous delivery of therapeutic agents and diagnostic probes.
local.identifier.orcidhttps://orcid.org/0000-0001-7597-9602
local.identifier.orcidhttps://orcid.org/0000-0002-3924-6521
local.identifier.orcidhttps://orcid.org/0000-0002-8703-4283
local.identifier.orcidhttps://orcid.org/0000-0002-5203-0944
local.identifier.orcidhttps://orcid.org/0000-0001-9625-8046
local.identifier.orcidhttps://orcid.org/0000-0002-7641-6585
local.identifier.orcidhttps://orcid.org/0000-0001-8812-3811
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0753332217303396?via%3Dihub

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