Metabolomic analysis of follicular fluid from women with Hashimoto Thyroiditis

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dc.creatorDiana Caroline da Silva Bastos
dc.creatorMaria Izabel Chiamolera
dc.creatorRenata Elen Silva
dc.creatorMaria do Carmo Borges de Souza
dc.creatorRoberto Azevedo Antunes
dc.creatorMarcelo Marinho Souza
dc.creatorAna Cristina Allemand Mancebo
dc.creatorPatrícia Cristina Fernandes Arêas
dc.creatorFernando Marcos dos Reis
dc.creatorEdson Guimarães Lo Turco
dc.creatorFlavia Fonseca Bloise
dc.creatorTania Maria Ortiga‑Carvalho
dc.date.accessioned2025-03-17T22:17:20Z
dc.date.accessioned2025-09-09T00:57:37Z
dc.date.available2025-03-17T22:17:20Z
dc.date.issued2023-08-02
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1038/s41598-023-39514-7
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1843/80730
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.subjectLíquido Folicular
dc.subjectFertilidade
dc.subjectDoença de Hashimoto
dc.subjectInfertilidade Feminina
dc.subject.otherThyroid diseases
dc.subject.otherFollicular fluid
dc.titleMetabolomic analysis of follicular fluid from women with Hashimoto Thyroiditis
dc.typeArtigo de periódico
local.citation.epage10
local.citation.spage1
local.citation.volume13
local.description.resumoHashimoto thyroiditis is an autoimmune disease characterized by hypothyroidism and a high level of anti-thyroid autoantibodies. It has shown to negatively impact female fertility; however, the mechanisms are unclear. Ovarian follicular fluid appears to be the key to understanding how Hashimoto thyroiditis affecst fertility. Thus, we aimed to evaluated the metabolic profile of follicular fluid and antithyroid autoantibody levels in the context of Hashimoto thyroiditis. We collected follicular fluid from 61 patients, namely 38 women with thyroid autoantibody positivity and 23 women as negative controls, undergoing in vitro fertilization treatment. Follicular fluid samples were analyzed using metabolomics, and thyroid autoantibodies were measured. Fifteen metabolites with higher concentrations in the follicular fluid samples from Hashimoto thyroiditis were identified, comprising five possible affected pathways: the glycerophospholipid, arachidonic acid, linoleic acid, alpha-linolenic acid, and sphingolipid metabolism pathways. These pathways are known to regulate ovarian functions. In addition, antithyroglobulin antibody concentrations in both serum and follicular fluid were more than tenfold higher in women with Hashimoto thyroiditis than in controls. Our data showed that the metabolic profile of follicular fluid is altered in women with Hashimoto thyroiditis, suggesting a potential mechanistic explanation for the association of this disease with female infertility.
local.identifier.orcidhttps://orcid.org/0009-0001-6035-0120
local.identifier.orcidhttps://orcid.org/0000-0002-2890-9094
local.identifier.orcidhttps://orcid.org/0000-0002-4425-4534
local.identifier.orcidhttps://orcid.org/0000-0002-3509-847X
local.identifier.orcidhttps://orcid.org/0000-0002-5207-2896
local.identifier.orcidhttps://orcid.org/0000-0002-0225-1132
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/s41598-023-39514-7

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