Physical training improves myocardial perfusion but not left ventricular function response to exercise in patients with microvascular angina

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dc.creatorEduardo Elias Vieira de Carvalho
dc.creatorJulio Cesar Crescencio
dc.creatorGiovani Luiz de Santi
dc.creatorLuciano Fonseca Lemos de Oliveira
dc.creatorPedro Vellosa Schwartzmann
dc.creatorLourenço Gallo Junior
dc.creatorJosé Antônio Marin Neto
dc.creatorMarcus Vinicius Simões
dc.date.accessioned2022-06-02T14:42:04Z
dc.date.accessioned2025-09-08T23:27:08Z
dc.date.available2022-06-02T14:42:04Z
dc.date.issued2019-09
dc.identifier.doihttps://doi.org/10.23736/S1824-4785.17.02930-2
dc.identifier.issn1827-1936
dc.identifier.urihttps://hdl.handle.net/1843/42190
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofQuarterly Journal of Nuclear Medicine and Molecular Imaging
dc.rightsAcesso Restrito
dc.subjectAngina microvascular
dc.subjectVentrículos do coração / fisiologia
dc.subjectExercícios físicos
dc.subject.otherMicrovascular angina
dc.subject.otherHeart ventricles - Physiology
dc.subject.otherPhysical exercise
dc.titlePhysical training improves myocardial perfusion but not left ventricular function response to exercise in patients with microvascular angina
dc.typeArtigo de periódico
local.citation.epage310
local.citation.issue3
local.citation.spage302
local.citation.volume63
local.description.resumoBACKGROUND: Patients with primary microvascular angina (PMA) commonly exhibit abnormal left ventricular function (LVF) during exercise, potentially owing to myocardial ischemia. Herein, we investigated in PMA patients the effect of the reduction of myocardial perfusion disorders, by using aerobic physical training, upon LVF response to exercise. METHODS: Overall, 15 patients (mean age, 53.7±8.9 years) with PMA and 15 healthy controls (mean age, 51.0±9.4 years) were studied. All subjects were subjected to baseline resting and exercise ventriculography, myocardial perfusion scintigraphy (MPS), and cardiopulmonary testing. PMA group members then participated in a 4-month physical training program and were reevaluated via the same methods applied at baseline. RESULTS: Baseline left ventricular ejection fraction (LVEF) determinations by ventriculography were similar for both groups (PMA, 67.7±10.2%; controls, 66.5±5.4%; P=0.67). However, a significant rise in LVEF seen in control subjects during exercise (75.3±6.2%; P=0.0001) did not materialize during peak exercise in patients with PMA (67.7±10.2%; P=0.47). Of the 12 patients in the PMA group who completed the training program, 10 showed a significant reduction in reversible perfusion defects during MPS. Nevertheless, LVEF at rest (63.5±8.7%) and at peak exercise (67.3±15.9%) did not differ significantly (P=0.30) in this subset. CONCLUSIONS: In patients with PMA, reduced left ventricular inotropic reserve observed during exercise did not normalize after improving myocardial perfusion through aerobic physical training.
local.identifier.orcidhttps://orcid.org/0000-0001-5026-335X
local.identifier.orcidhttps://orcid.org/0000-0003-3455-2463
local.identifier.orcidhttp://orcid.org/0000-0002-0706-0933
local.identifier.orcidhttps://orcid.org/ 0000-0002-8651-8833
local.identifier.orcidhttps://orcid.org/ 0000-0001-6553-8387
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIA
local.publisher.initialsUFMG
local.url.externahttps://www.minervamedica.it/en/journals/nuclear-med-molecular-imaging/article.php?cod=R39Y2019N03A0302#

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