Resveratrol effects on metabolic syndrome features: a systematic review and meta-analysis

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dc.creatorGislaine Cândida Batista Jorge
dc.creatorAntônio Sérgio Barcala Jorge
dc.creatorDeborah de Farias Lelis
dc.creatorDaniel Erikson Oliveira Santos
dc.creatorAntônio Henrique Barcala Jorge
dc.creatorRenato Sobral Monteiro Júnior
dc.creatorSergio Henrique Sousa Santos
dc.date.accessioned2025-08-05T16:34:47Z
dc.date.accessioned2025-09-08T23:32:34Z
dc.date.available2025-08-05T16:34:47Z
dc.date.issued2024-05-22
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.3390/endocrines5020016
dc.identifier.issn2673-396X
dc.identifier.urihttps://hdl.handle.net/1843/84043
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Aberto
dc.subjectSíndrome metabólica
dc.subjectObesidade
dc.subjectPolifenóis
dc.subjectGlicose
dc.subjectMeta-análise
dc.titleResveratrol effects on metabolic syndrome features: a systematic review and meta-analysis
dc.typeArtigo de periódico
local.citation.epage243
local.citation.issue2
local.citation.spage225
local.citation.volume5
local.description.resumoResveratrol is a natural polyphenol with important anti-inflammatory and antioxidant properties for treating cardiometabolic disorders. Therefore, the present meta-analysis aimed to review and investigate the oral resveratrol supplementation effects on metabolic syndrome (MetS) components. The bibliographic search was carried out in 2023 in the following databases: PubMed, Web of Science, and Scopus. Studies that investigated the oral resveratrol effects on the MetS parameters were included. Statistical analyses were performed using RevMan Software V.5.3. The main findings showed that resveratrol significantly decreased systolic and diastolic blood pressure while having no significant effects on waist circumference and high-density lipoprotein levels. In addition, glucose level was significantly decreased in the subgroup of studies reporting change from baseline means, although the overall effect was not statistically significant (p = 0.81), while triglyceride levels were increased after the treatment period. In conclusion, the present meta-analysis evidenced the potential therapeutic effect of resveratrol on improving some MetS features, especially regarding systolic blood pressure, diastolic blood pressure, and glucose reduction; however, the results are still borderline and sometimes controversial, which might be justified by the methodological and statistical heterogeneity of the studies, with the latter varying from 17 to 57%.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2673-396X/5/2/16

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