Gastrointestinal symptoms predictors of health-related quality of life in patients with inflammatory bowel disease

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dc.creatorJames Varni
dc.creatorRobert Shulman
dc.creatorMariella Self
dc.creatorShehzad Saeed
dc.creatorAshish Patel
dc.creatorSamuel Nurko
dc.creatorDeborah Neigut
dc.creatorMiguel Saps
dc.creatorJames Franciosi
dc.creatorJolanda Denham
dc.creatorGeorge Zacur
dc.creatorChelsea Dark
dc.creatorCristiane Baccin Bendo Neves
dc.creatorJohn Pohl
dc.date.accessioned2024-05-09T18:17:33Z
dc.date.accessioned2025-09-08T23:39:00Z
dc.date.available2024-05-09T18:17:33Z
dc.date.issued2016-12
dc.identifier.doihttps://doi.org/10.1097/MPG.0000000000001428
dc.identifier.issn0277-2116
dc.identifier.urihttps://hdl.handle.net/1843/68150
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutrition
dc.rightsAcesso Restrito
dc.subjectCrohn disease
dc.subjectLocal symptoms
dc.subjectInflammatory bowel diseases
dc.subjectPatient reported outcome measures
dc.subjectIndicators of quality of life
dc.subjectColitis, ulcerative
dc.subject.otherCrohn disease
dc.subject.otherGastrointestinal symptoms
dc.subject.otherInflammatory bowel disease
dc.subject.otherPatient-reported outcomes
dc.subject.otherPedsQL
dc.subject.otherUlcerative colitis
dc.titleGastrointestinal symptoms predictors of health-related quality of life in patients with inflammatory bowel disease
dc.typeArtigo de periódico
local.citation.epagee192
local.citation.issue6
local.citation.spagee186
local.citation.volume63
local.description.resumoObjectives: The aim of the study was to investigate the multidimensional gastrointestinal symptoms predictors of generic health-related quality of life (HRQOL) in pediatric patients with inflammatory bowel disease from the perspectives of pediatric patients and parents. Methods: The Pediatric Quality of Life Inventory Gastrointestinal Symptoms Scales and Pediatric Quality of Life Inventory 4.0 Generic Core Scales were completed in a 9-site study by 260 families of patients with inflammatory bowel disease. Gastrointestinal Symptoms Scales measuring stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were identified as clinically important symptom differentiators from healthy controls based on prior findings, and subsequently tested for bivariate and multivariate linear associations with overall HRQOL (Generic Core Scales). Results: Stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were significantly associated with decreased HRQOL in bivariate analyses (P < 0.001). In predictive models utilizing hierarchical multiple regression analyses controlling for age, sex, and race/ethnicity, gastrointestinal symptoms accounted for an additional 40% of the variance in patient self-reported HRQOL (P < 0.001) and 37% of the variance in parent proxy-reported HRQOL (P < 0.001), reflecting large effect sizes. Stomach pain, food and drink limits, and constipation were significant individual patient-reported predictors after controlling for the other gastrointestinal symptoms in the predictive models. Conclusions: Patient-reported gastrointestinal symptoms differentially predicted HRQOL. Identifying the specific gastrointestinal symptoms from a standardized multidimensional gastrointestinal symptoms profile that are the most important predictors from the patient perspective facilitates a patient-centered approach for interventions designed to ameliorate impaired HRQOL.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1097/MPG.0000000000001428

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