Prognostic significance of hmsh2, hmsh3, and hmsh6 expression in ameloblastoma

Página do item simplificado
dc.creatorGleyson Kleber do Amaral Silva
dc.creatorAlan Roger dos Santos-Silva
dc.creatorFelipe Paiva Fonseca
dc.creatorPablo Agustin Vargas
dc.creatorCeleste Sánchez-Romero
dc.creatorVivian Petersen Wagner
dc.creatorManoela Domingues Martins
dc.creatorHélder Antônio Rebelo Pontes
dc.creatorEduardo Rodrigues Fregnani
dc.creatorFernando Augusto Soares
dc.creatorOslei Paes de Almeida
dc.creatorAndré Caroli Rocha
dc.date.accessioned2023-09-20T19:12:00Z
dc.date.accessioned2025-09-09T00:17:39Z
dc.date.available2023-09-20T19:12:00Z
dc.date.issued2017-09
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2017.05.511
dc.identifier.issn22124403
dc.identifier.urihttps://hdl.handle.net/1843/58812
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsAcesso Restrito
dc.subjectProteins
dc.subjectTooth
dc.subjectCarcinoma
dc.subjectAmeloblastoma
dc.subjectMutation
dc.subjectRecurrence
dc.titlePrognostic significance of hmsh2, hmsh3, and hmsh6 expression in ameloblastoma
dc.typeArtigo de periódico
local.citation.epage295
local.citation.issue3
local.citation.spage286
local.citation.volume124
local.description.resumoObjective: The aim of this study was to investigate hMutS proteins in developing human tooth, ameloblastomas, and ameloblastic carcinoma and to determine whether the expression of these proteins has any prognostic potential. Study design: Ten cases of developing human tooth, 39 ameloblastomas, and 2 ameloblastic carcinomas were used to determine the distribution of the proteins during the process of carcinogenesis. Simultaneously, another sample of 73 ameloblastomas was arranged in tissue microarray, and their clinical, microscopic, and radiographic features; treatment outcome; presence of BRAF-V600E mutation; and follow-up data were assessed to determine the prognostic relevance of the expression of hMutS (hMSH2, hMSH3, hMSH6) and Ki-67. hMSH2 and hMSH6 were significantly downexpressed in ameloblastomas (P = .0059) compared with developing human tooth (P < .0001). Results: hMSH2, hMSH3 expression were significantly associated with BRAF-V600E mutation (P < .05). Simultaneous overexpression of hMutS was associated with recurrence (P = .035); however, these did not predict the disease-free survival of patients (P > .05). Conclusions: hMutS proteins are downregulated in ameloblastoma; moreover, simultaneous overexpression of these proteins in ameloblastoma was associated with recurrence but did not predict disease-free survival.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440317308313?via%3Dihub

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG