MMP-1 and MMP-8 expression in giant-cell fibroma and inflammatory fibrous hyperplasia

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dc.creatorHenrique Climeck de Oliveira
dc.creatorAna Maria Trindade Grégio
dc.creatorLuciana Reis Azevedo Alanis
dc.creatorSérgio Aparecido Ignácio
dc.creatorJean Nunes dos Santos
dc.creatorAntonio Adilson Soares de Lima
dc.creatorAline Cristina Batista Rodrigues Johann
dc.creatorAndré Tschoeke
dc.creatorGabriele Claudino da Cruz
dc.creatorLúcia Noronha
dc.creatorRafaela Scariot de Moraes
dc.creatorRicardo Alves Mesquita
dc.creatorMaria Cássia Ferreira de Aguiar
dc.creatorPatrícia Carlos Caldeira
dc.creatorMarina de Oliveira Ribas
dc.date.accessioned2024-07-25T19:01:09Z
dc.date.accessioned2025-09-09T00:02:46Z
dc.date.available2024-07-25T19:01:09Z
dc.date.issued2016-12
dc.identifier.doihttps://doi.org/10.1016/j.prp.2016.10.002
dc.identifier.issn1618-0631
dc.identifier.urihttps://hdl.handle.net/1843/71502
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPathology - Research and Practice
dc.rightsAcesso Restrito
dc.subjectCollagen
dc.subjectMatrix metalloproteinase 1
dc.subjectMatrix metalloproteinase 8
dc.subjectImmunohistochemistry
dc.subjectHyperplasia
dc.subjectFibroma
dc.subjectMouth mucosa
dc.subject.otherKeywords Collagen Metalloproteinase-8 Metalloproteinase-1
dc.titleMMP-1 and MMP-8 expression in giant-cell fibroma and inflammatory fibrous hyperplasia
dc.typeArtigo de periódico
local.citation.epage1112
local.citation.issue12
local.citation.spage1108
local.citation.volume212
local.description.resumoThe aim of this study is to compare the immunoexpression of metalloproteinases 1 and 8 in giant-cell fibroma, inflammatory fibrous hyperplasia and normal mucosa. Twenty-two cases of giant-cell fibroma, inflammatory fibrous hyperplasia and oral mucosa (control) each were subjected to immunohistochemistry using anti-metalloproteinase-1 and anti-metalloproteinase-8 antibodies. Eight images of each case were captured and analysed through the a) application of a count grid to count the number of positive neutrophils, macrophages, lymphocytes, plasma cells, fibroblasts and blood vessels to obtain the percentage of staining and b) semi-automated segmentation quantifying the stained area in square micrometres. Statistical tests included ANOVA Two-way, Kruskal Wallis and Games-Howell, with a significance level of 5%. An increased percentage of metalloproteinase-1-immunopositive blood vessels were observed in giant-cell fibroma (26.6 ± 22.4; p = 0.02) and inflammatory fibrous hyperplasia (34.3 ± 31.5; p = 0.01) compared with the control group (19.6 ± 9.2). No significant differences in inflammatory cells, fibroblasts and total area of metalloproteinase-1 and −8 were noted among the three groups. Metalloproteinase-1 apparently acts within the pathogenesis of giant-cell fibroma and inflammatory fibrous hyperplasia.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0344033816305313

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