Honey activity on the proliferation and migration of oral squamous cell carcinoma: in vitro and bioinformatic analysis

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dc.creatorEliane Macedo Sobrinho Santos
dc.creatorKattyanne de Souza Costa
dc.creatorAndre Luiz Sena Guimaraes
dc.creatorLucyana Conceiçao Farias
dc.creatorHercules Otacílio Santos
dc.creatorJuliana Rezende Sá Miranda Goncalves
dc.creatorAnna Christina de Almeida
dc.creatorIgor Viana Brandi
dc.creatorAlex Sander Rodrigues Cangussu
dc.creatorJanainne Nunes Alves
dc.creatorSabrina Ferreira de Jesus
dc.creatorRicardo Jardim Neiva
dc.date.accessioned2022-06-08T12:31:27Z
dc.date.accessioned2025-09-09T01:12:53Z
dc.date.available2022-06-08T12:31:27Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.5897/SRE2018.6590
dc.identifier.issn1992-2248
dc.identifier.urihttps://hdl.handle.net/1843/42348
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific research and essays
dc.rightsAcesso Aberto
dc.subjectMel de abelha -- Jequitinhonha, Rio, Vale (MG e BA)
dc.subjectAroeira do sertão
dc.subjectAbelha-européia
dc.subjectMel -- Uso terapêutico
dc.titleHoney activity on the proliferation and migration of oral squamous cell carcinoma: in vitro and bioinformatic analysis
dc.typeArtigo de periódico
local.citation.epage171
local.citation.issue15
local.citation.spage158
local.citation.volume13
local.description.resumoThis study aimed to investigate, in oral squamous carcinoma cells (OSCC), the antineoplastic effect of Apis mellifera honey produced from Aroeira and wildflower, in the region of Jequitinhonha River Valley, Brazil. Furthermore, we investigate the molecular mechanism of honey performance through bioinformatic analysis. Honey and OSCC-related gene list were screened using GeneCards. The online tool STRING was used to identify the potential interaction networks of protein products of these genes. The genes with the highest weighted number of links (WNL) were called leader genes. GO and KEGG pathway analysis was performed to classify the genes. We use a search tool STITCH for interactions of chemicals-proteins. The chemical characterization of honey and its antiproliferative and antimigratory effects in SCC-9 cell lines was evaluated in vitro. The analysis of the interaction network obtained from the STRING database indicated by the following leader genes: TNF, IL6 and HDAC1. GO analysis for the honey, and OSCC-related proteins revealed that leader genes-regulated cancers genes were markedly enriched in some functions. Through the chemical characterization, the bioactive classes: steroids/triterpenoids, flavonoids, saponins, alkaloids, and tannins were identified. Polyphenols act in activating CASP3 and TP53 and inhibit the action of DNMT1. The honey produced from Aroeira and wildflower reduced proliferative phenotype and migration of OSCC cells.
local.identifier.orcidhttps://orcid.org/ 0000-0001-9836-4117
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://academicjournals.org/journal/SRE/article-abstract/60EC8D659093i

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