Chemical characterization and anti-inflammatory assessment of the hydroethanolic extract of Fridericia chica

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dc.creatorIsabella Kuniko Tavares Magalhães Takenaka
dc.creatorJuliana Mendes Amorim
dc.creatorPatrícia Aparecida Vieira de Barros
dc.creatorGeraldo Célio Brandão
dc.creatorSara Moreira Lopes Contarini
dc.creatorÉricka Lorenna de Sales Souza e Melo
dc.creatorCamila Megale de Almeida-Leite
dc.creatorFlaviano dos Santos Martins
dc.creatorValbert Nascimento Cardoso
dc.creatorRachel Oliveira Castilho
dc.creatorSimone Odília Antunes Fernandes
dc.date.accessioned2022-05-19T19:23:47Z
dc.date.accessioned2025-09-08T23:54:36Z
dc.date.available2022-05-19T19:23:47Z
dc.date.issued2020
dc.identifier.doi10.1007/s43450-020-00085-7
dc.identifier.issn1981-528X
dc.identifier.urihttps://hdl.handle.net/1843/41833
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista Brasileira de Farmacognosia
dc.rightsAcesso Restrito
dc.subjectPerfil químico
dc.subjectFridericia chica
dc.subjectPariri
dc.subjectPlantas Medicinais
dc.subjectCromatografia líquida
dc.subjectEspectrometria de massas
dc.subjectCamundongos
dc.subject.otherBacterial translocation
dc.subject.otherChemotherapy
dc.subject.otherFlavonoids rich extract
dc.subject.otherIntestinal mucositis
dc.subject.otherIntestinal permeability
dc.subject.otherPariri
dc.titleChemical characterization and anti-inflammatory assessment of the hydroethanolic extract of Fridericia chica
dc.typeArtigo de periódico
local.citation.epage567
local.citation.spage559
local.citation.volume30
local.description.resumoFridericia chica (Bonpl.) L.G. Lohmann, Bignoniaceae, is an Amazonian species known as “pariri” or “crajiru” that is included in the Brazilian National List of Medicinal Plants of Interest to the Unified Health System (Renisus). This herbal remedy is traditionally used as an infusion to treat diarrhea, anemia, inflammation, symptoms of mucositis, and frequent complications of chemotherapy. This study aimed to characterize the chemical profile of the hydroethanolic extract of F. chica and to assess its intestinal anti-inflammatory activity. The chemical profile of the leaves was determined by ultra-performance liquid chromatography coupled to mass spectrometry, and its potential anti-inflammatory activity in the gut was evaluated in mucositis induced by 5-fluorouracil. Three novel compounds from this the species were identified 6,7,3′,4′-tetrahydroxy-5-methoxyflavilium-O-glucuronide, scutellarein-O-glucuronide, and 5-methyl-scutellarein-O-glucuronide, as well as flavones and anthocyanidins that have been previously described. Mice received the hydroethanolic extract (300 mg/kg) for 9 days, and no signs of toxicity were observed. After 72 h of 5-fluorouracil administration, intestinal permeability, bacterial translocation, myeloperoxidase activity, eosinophil peroxidase activity, and histological analyses were performed. Treatment with the analyzed extract was beneficial, as it normalized intestinal permeability, bacterial translocation, myeloperoxidase activity/eosinophil peroxidase and preserved intestinal epithelium architecture. This study provides new insights into the chemical composition and biological activity of the polar extracts from “pariri”, an important Amazonian crude medicinal drug.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s43450-020-00085-7

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