Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition

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dc.creatorAna Carolina Sena Avellar
dc.creatorMariana Naves Oliveira
dc.creatorFelipe Caixeta
dc.creatorRafaela Cristina Vieira e Souza
dc.creatorElaine Speziali Faria
dc.creatorAndréa Teixeira
dc.creatorAna Maria Caetano Faria
dc.creatorGabriela Silveira Nunes
dc.creatorTatiani Uceli Maioli
dc.date.accessioned2024-03-21T14:19:56Z
dc.date.accessioned2025-09-08T23:51:21Z
dc.date.available2024-03-21T14:19:56Z
dc.date.issued2022-06-19
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fimmu.2022.910807
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/1843/66319
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Immunology
dc.rightsAcesso Aberto
dc.subjectDiabetes Mellitus
dc.subjectGravidez
dc.subjectColostro
dc.subjectSistema Imunitário
dc.subjectCitocinas
dc.subjectQuimiocinas
dc.subjectPeptídeos e Proteínas de Sinalização Intercelular
dc.subject.otherGestational diabetes mellitus
dc.subject.otherColostrum
dc.subject.otherImmune system
dc.subject.otherCytokines
dc.subject.otherChemokines
dc.subject.otherGrowth factors
dc.titleGestational Diabetes Mellitus Changes Human Colostrum Immune Composition
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage910807
local.citation.volume13
local.description.resumoBreast milk is considered a complete food for babies. Up to 7 days postpartum, it is known as colostrum, rich in immunological compounds, responsible for providing nutrition and ensuring immune protection. However, some maternal factors, such as gestational diabetes mellitus (GDM), can change the concentration of bioactive compounds present in the colostrum and may affect the development of the newborn’s immune system. The effect of GDM on colostrum cytokine, chemokine, and growth factors is not well described. Thus, the present study evaluated whether the occurrence of GDM changes the concentration of biomarkers in the colostrum. A cross-sectional study was carried out on postpartum women who had healthy pregnancies and women who had been diagnosed with GDM. A sample of colostrum was collected for Luminex analysis. Our results showed that GDM mothers had higher secretion of cytokines and chemokines in the colostrum, with a higher concentration of IFN-g, IL-6, and IL-15, and a lower concentration of IL-1ra. Among growth factors, we identified a decreased concentration of GM-CSF in the colostrum of GDM mothers. Thus, the data obtained support the idea that the disease leads to immune alterations in the colostrum.
local.identifier.orcidhttps://orcid.org/0000-0002-7538-3208
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.departmentENFERMAGEM - ESCOLA DE ENFERMAGEM
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.910807/full

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