Novel copper(II) coordination polymer containing the drugs nalidixic acid and 8-hydroxyquinoline: evaluation of the structural, magnetic, electronic, and antitumor properties

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dc.creatorAlexandre Bizzotto de Carvalho
dc.creatorÍvina Paula de Souza
dc.creatorLídia Maria de Andrade
dc.creatorIldefonso Binatti
dc.creatorEmerson Fernandes Pedroso
dc.creatorKlaus Wilhelm Heinrich Krambrock
dc.creatorWillian Xerxes Coelho Oliveira
dc.creatorElene Cristina Pereira Maia
dc.creatorPriscila Pereira Silva Caldeira
dc.date.accessioned2022-11-03T19:02:51Z
dc.date.accessioned2025-09-08T22:58:27Z
dc.date.available2022-11-03T19:02:51Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.identifier.doihttps://doi.org/10.1016/j.poly.2018.09.046
dc.identifier.issn02775387
dc.identifier.urihttps://hdl.handle.net/1843/46876
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPolyhedron
dc.rightsAcesso Restrito
dc.subjectPropriedades magnéticas
dc.subject.otherNalidixic acid
dc.subject.other8-hydroxyquinoline
dc.subject.otherCopper(II) coordination polymer
dc.subject.otherAntitumoral activity
dc.subject.otherMagnetic properties
dc.titleNovel copper(II) coordination polymer containing the drugs nalidixic acid and 8-hydroxyquinoline: evaluation of the structural, magnetic, electronic, and antitumor properties
dc.typeArtigo de periódico
local.citation.epage319
local.citation.spage312
local.citation.volume156
local.description.resumoHerein we describe the synthesis, structural characterization, physical/spectroscopic studies and evaluation of the antitumoral activity of a new copper(II) coordination polymer, [Cu(ndx)(8-hq)]n, where H(ndx) is nalidixic acid and H(8-hq) is 8-hydroxyquinoline. Single crystal X-ray diffraction shows a zigzag polymeric chain, where the adjacent copper atoms are connected via anti-anti μ-carboxylate bridge of ndx. This structural feature is quite different from those previously proposed for quinolone complexes. Variable-temperature magnetic susceptibility measurements showed weak antiferromagnetic interactions between the paramagnetic copper centers (−0.49 cm−1). In solution, the compound exists as neutral mononuclear species and it can inhibit the growth of a human chronic myelogenous leukemia cell line (K562) in a concentration-dependent manner with IC50 value lower than those of the corresponding free ligands. At similar doses, the compound does not alter the viability of human keratinocytes (HaCaT cell line). Spectroscopic data and viscosity measurements show that the compound binds to DNA (Kb = 2.47 × 105 M−1) interacting with it by a non-intercalative mode.
local.identifier.orcidhttps://orcid.org/0000-0002-8699-6165
local.identifier.orcidhttps://orcid.org/0000-0002-0454-0026
local.identifier.orcidhttps://orcid.org/0000-0001-8379-6638
local.identifier.orcidhttps://orcid.org/0000-0002-7562-0285
local.identifier.orcidhttps://orcid.org/0000-0003-0722-5352
local.identifier.orcidhttps://orcid.org/0000-0003-2699-6232
local.identifier.orcidhttps://orcid.org/0000-0002-9983-3840
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0277538718305989

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