Wheat gluten intake increases weight gain and adiposity associated with reduced thermogenesis and energy expenditure in an animal model of obesity

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dc.creatorRachel Horta Freire
dc.creatorLuciana Rodrigues Fernandes
dc.creatorRachel Bacha Silva
dc.creatorBruna Scherr Laignier Coelho
dc.creatorLaís Pires Teixeira de Araújo
dc.creatorLucas Secchim Ribeiro
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorPaulo Marcelo de Andrade Lima
dc.creatorRaquel Silva Araújo
dc.creatorSergio Henrique Sousa Santos
dc.creatorCândido Celso Coimbra
dc.creatorValbert Nascimento Cardoso
dc.creatorJacqueline Isaura Alvarez-Leite
dc.date.accessioned2022-08-15T14:52:11Z
dc.date.accessioned2025-09-09T01:27:28Z
dc.date.available2022-08-15T14:52:11Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.identifier.doi10.1038/ijo.2015.204
dc.identifier.issn1476-5497
dc.identifier.urihttps://hdl.handle.net/1843/44257
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Obesity
dc.rightsAcesso Restrito
dc.subjectObesidade
dc.subjectPeso corporal
dc.subjectGlúten
dc.subjectTecido adiposo
dc.titleWheat gluten intake increases weight gain and adiposity associated with reduced thermogenesis and energy expenditure in an animal model of obesity
dc.typeArtigo de periódico
local.citation.epage486
local.citation.spage479
local.citation.volume40
local.description.resumoBackground/Objectives: the association between gluten and body weight is inconsistent. Previously, we showed that a gluten-free diet reduces weight gain without changing food intake in mice fed high-fat diets. In the present study, we investigated the effects of gluten intake on fat metabolism, thermogenesis and energy expenditure in mice fed a standard or high-fat diet. Methods: mice were fed four different experimental diets during 8 weeks: a control-standard diet (CD), a CD added with 4.5% of wheat gluten (CD-G), a high-fat diet (HFD) and a HFD added with 4.5% of wheat gluten (HFD-G). After 8 weeks, the mice received 99mTc-radiolabeled gluten orally to study gluten absorption and biodistribution or they underwent indirect calorimetry. After killing, subcutaneous and brown adipose tissues (SAT and BAT) were collected to assess thermogenesis-related protein expression. Lipid metabolism was studied in adipocyte cultures from the four groups. Results: despite having had the same energy intake, CD-G and HFD-G mice exhibited increased body weight and fat deposits compared with their respective controls. 99mTc-GLU or its peptides were detected in the blood, liver and visceral adipose tissue, suggesting that gluten can even reach extraintestinal organs. Uncoupling protein-1 expression was reduced in the BAT of HFD-G and in the SAT of CD-G and HFD-G mice. Indirect calorimetry showed lower oxygen volume consumption in CD-G and HFD-G groups compared with their controls. In HFD mice, daily energy expenditure was reduced with gluten intake. Gluten also reduced adiponectin, peroxisome proliferator-activated receptor (PPAR)-α and PPARγ and hormone-sensitive lipase in cultures of isolated adipocytes from HFD mice, whereas in the CD-G group, gluten intake increased interleukin-6 expression and tended to increase that of tumor necrosis factor. Conclusions: wheat gluten promotes weight gain in animals on both HFD and CD, partly by reducing the thermogenic capacity of adipose tissues.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/ijo2015204

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