Comparison of miRNA expression profiles in individuals with chronic or aggressive periodontitis

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dc.creatorSergio Antonucci Amaral
dc.creatorThais Santos Fontes Pereira
dc.creatorJoão Artur Ricieri Brito
dc.creatorSheila Cavalca Cortelli
dc.creatorJose Roberto Cortelli
dc.creatorRicardo Santiago Gomez
dc.creatorFernando de Oliveira Costa
dc.creatorLuis Otávio de Miranda Cota
dc.date.accessioned2025-01-06T18:37:57Z
dc.date.accessioned2025-09-09T01:26:15Z
dc.date.available2025-01-06T18:37:57Z
dc.date.issued2019-03
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/odi.12994
dc.identifier.issn1601-0825
dc.identifier.urihttps://hdl.handle.net/1843/79043
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Diseases
dc.rightsAcesso Aberto
dc.subjectAggressive periodontitis
dc.subjectChronic periodontitis
dc.subjectMicroRNAs
dc.subjectGene expression
dc.subject.otherMiRNA
dc.subject.otheraggressive periodontitis
dc.subject.otherperiodontitis chronic
dc.subject.otherPathogenesis.
dc.titleComparison of miRNA expression profiles in individuals with chronic or aggressive periodontitis
dc.typeArtigo de periódico
local.citation.epage568
local.citation.issue2
local.citation.spage561
local.citation.volume25
local.description.resumoObjectives: MicroRNAs (miRNAs) may play an important role in inflammatory response. However, the involvement of miRNAs in the pathogenesis of periodontitis is unclear. The present study aimed to compare the miRNA expression profiles in individuals with chronic (CP) or aggressive (AP) periodontitis. Materials and methods: Eighteen non-smoker individuals (CP = 9 and AP = 9) without any history of systemic diseases or previous periodontal therapies were selected at the Clinics of Periodontology from the Federal University of Minas Gerais. Gingival tissue samples were collected during the initial periodontal therapy. miRNAs were isolated, and expression patterns of 754 miRNAs were assessed with a quantitative miRNA PCR array. miRNAs expression profiles were compared between CP and AP groups. Results: There were no differences observed in the miRNAs expression profiles between CP and AP (p > 0.05). According to the microarray analyses, the most expressed miRNAs in both groups were hsa-miR-1274b, hsa-let-7b-5p, hsa-miR-24-3p, hsa-miR-19b-3p, hsa-miR-720, hsa-miR-126-3p, hsa-miR-17-3p and hsa-miR-21-3p. Conclusion: Findings suggested no differences in miRNAs expression profiles between chronic and aggressive forms of periodontitis. The overexpression of specific miRNAs could provide insights into the pathogenesis of both forms of the disease.
local.identifier.orcidhttps://orcid.org/0000-0003-0809-6935
local.identifier.orcidhttps://orcid.org/0000-0001-5147-0705
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0002-7687-1238
local.identifier.orcidhttps://orcid.org/0000-0003-1517-5842
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/odi.12994

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