Dietary lipids management: are there any benefits from the prevention and treatment of 4T1 murine breast carcinoma?

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dc.creatorNicolle Camilla da Silva
dc.creatorYasmim de Silva
dc.creatorJacqueline Aparecida Takahashi
dc.creatorSilvia Andrade
dc.creatorGeovanni Cassali
dc.creatorDirce Ribeiro de Oliveira
dc.date.accessioned2025-03-17T21:00:17Z
dc.date.accessioned2025-09-08T23:46:53Z
dc.date.available2025-03-17T21:00:17Z
dc.date.issued2023-08
dc.format.mimetypepdf
dc.identifier.issn1678-2690
dc.identifier.urihttps://hdl.handle.net/1843/80723
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnais da Academia Brasileira de Ciências
dc.rightsAcesso Aberto
dc.subjectLipoproteínas
dc.subjectInflamação
dc.subjectÓleos de peixe
dc.subjectÓleos vegetais
dc.subjectCâncer
dc.subject.othern-3/n-6 ratio
dc.subject.other4T1 murine breast cancer model
dc.subject.otherAngiogenesis
dc.subject.otherInflammation
dc.subject.otherLipoprotein
dc.titleDietary lipids management: are there any benefits from the prevention and treatment of 4T1 murine breast carcinoma?
dc.typeArtigo de periódico
local.citation.epage18
local.citation.issue2
local.citation.spage1
local.citation.volume95
local.description.resumoThis study investigated the effect of vegetable and fish oils with different n-3 / n-6 PUFAS ratios on the lipoprotein profile and on the development of murine breast cancer 4T1. Female Balb/c mice (6-7 weeks) received diets containing 4.0% fat during seven weeks. On the fourth week, animals were inoculated into the posterior left flank with 2.5 × 106 4T1 cells. Body weight and food intake were registered and the profile serum lipoproteins was determined. Tumor volume, histopathological and immunohistochemical studies, myeloperoxidase and N-acetylglucosaminidase activities, TNF-α, hemoglobin and VEGF levels were analysed. The highest n-3 / n-6 ratio was found in fish oil (15.8:1), followed by linseed (2.4:1), canola (1:2.1) and soybean (1:9.4) oils. Body weight, food and caloric intake, lipoprotein profile, tumor weight, tumor evolution and histopathological analysis were not different. Canola oil increased cell proliferation when compared to soybean oil, and fish oil changed the inflammatory response and increased VEGF in tumors compared to other groups. The type of fatty acid and the high ratio of n-3 / n-6 PUFAs in the diet influenced cell proliferation and inflammation in the tumor differentially, highlighting the increase of neutrophils and VEGF levels in animals fed on fish oil.
local.identifier.orcidhttps://orcid.org/0000-0002-7951-3743
local.identifier.orcidhttps://orcid.org/0009-0005-9643-8190
local.identifier.orcidhttps://orcid.org/0000-0002-8831-1609
local.identifier.orcidhttps://orcid.org/0000-0001-5059-2807
local.identifier.orcidhttps://orcid.org/0000-0002-5650-6743
local.identifier.orcidhttps://orcid.org/0000-0003-4592-0508
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/aabc/a/4HpFm4rjMMmVNytyDWjPnGf/?format=pdf&lang=endoi:10.1590/0001-3765202320210330

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