Warfarin drug interaction with vitamin K and other foodstuffs
| dc.creator | Elaine de Carvalho Minighini | |
| dc.creator | Kellen Pereira Bragança | |
| dc.creator | Lucilene Rezende Anastácio | |
| dc.date.accessioned | 2022-04-09T00:34:00Z | |
| dc.date.accessioned | 2025-09-08T23:48:17Z | |
| dc.date.available | 2022-04-09T00:34:00Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | La vitamina K se encuentra en concentraciones más altas en plantas de color verde oscuro y en aceites vegetales. La ingesta adecuada de vitamina K es de 90 y 120 μg/día para hombres y mujeres adultos mayores, respectivamente. La función principal de la vitamina K es actuar como un cofactor enzimático para la síntesis de protrombina hepática, factores de coagulación de la sangre y proteínas anticoagulantes. Entre los muchos anticoagulantes disponibles destaca la warfarina, un antagonista de la vitamina K, que ejerce sus efectos anticoagulantes al inhibir la síntesis de la vitamina K1 y la vitamina KH2. Desde el inicio de la terapia, es necesario que los pacientes realicen el monitoreo a través del tiempo de protrombina y la proporción normalizada internacional. Sin embargo, se sabe que una ingesta muy baja y/o fluctuaciones en la ingesta de vitamina K son tan dañinas como un consumo alto. Además, otros alimentos pueden interactuar con la warfarina, a pesar de su contenido de vitamina K. El objetivo de este estudio fue recopilar información sobre la interacción de los medicamentos de la warfarina con la vitamina K y con los suplementos dietéticos y otros alimentos. | |
| dc.description.sponsorship | FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais | |
| dc.description.sponsorship | CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior | |
| dc.description.sponsorship | Outra Agência | |
| dc.format.mimetype | ||
| dc.identifier.doi | 10.4067/S0717-75182020000300470 | |
| dc.identifier.issn | 0717-7518 | |
| dc.identifier.uri | https://hdl.handle.net/1843/40952 | |
| dc.language | eng | |
| dc.publisher | Universidade Federal de Minas Gerais | |
| dc.relation.ispartof | Revista Chilena de Nutrición | |
| dc.rights | Acesso Aberto | |
| dc.subject | Interação medicamentosa | |
| dc.subject | Varfarina | |
| dc.subject | Vitamina K | |
| dc.subject | Alimentos | |
| dc.subject.other | Drug-food interaction | |
| dc.subject.other | International Normalized Ratio | |
| dc.subject.other | Phylloquinone | |
| dc.subject.other | Sources | |
| dc.subject.other | Warfarin | |
| dc.title | Warfarin drug interaction with vitamin K and other foodstuffs | |
| dc.title.alternative | Interacción de la droga warfarina con la vitamina K y otros productos alimenticios | |
| dc.type | Artigo de periódico | |
| local.citation.epage | 477 | |
| local.citation.issue | 3 | |
| local.citation.spage | 470 | |
| local.citation.volume | 47 | |
| local.description.resumo | Vitamin K is found in higher concentrations in dark green plant and in vegetable oils. The adequate intake of vitamin K is 90 and 120μg/day for adult elderly men and women, respectively. The main function of vitamin K is to act as an enzymatic cofactor for hepatic prothrombin synthesis, blood coagulation factors, and anticoagulant proteins. Prominent among the many available anticoagulants is warfarin, an antagonist of vitamin K, which exerts its anticoagulant effects by inhibiting the synthesis of vitamin K1 and vitamin KH2. From the beginning of the therapy it is necessary that the patients carry out the monitoring through the prothrombin time and the international normalized ratio. However, it is known that very low intake and/or fluctuations in vitamin K intake are as harmful as high consumption. In addition, other foods can interact with warfarin, despite their content of vitamin K. The aim of this study was to gather information on the drug interaction of warfarin with vitamin K and with dietary supplements and other foods. | |
| local.publisher.country | Brasil | |
| local.publisher.department | FAR - DEPARTAMENTO DE ALIMENTOS | |
| local.publisher.initials | UFMG | |
| local.url.externa | https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182020000300470 |