A inter-relação entre sistema imuno-neuroendócrino na artrite reumatóide

Abstract

The immunological system that protects the organism against internal and external aggression has its function modulate by the neuroendocrine system. The psych neuroendocrinology is the scientific field that studies its interactions on the body. Cytokine, hormones and neuropeptides are the chemical messengers. There is evidence involving the endocrine system, which is connectedto the immune system. Also, its evidence is influenced by organic responds of stress and depression. The unbalancing of the neuroendocrine system compromises the immune system increasing the risk of developing disabilities, such as auto immune diseases. Besides, it contributes to increase inflammatory diseases. The rheumatoid arthritis inflammation is characterized as a chronic inflammation, very persistent and based on qualitative and quantitative aspects of immunological homeostasis. Livingwith a painful sickness like rheumatoid arthritis may be a source of stress that intensifies the inflammation resulting so much pain for patients. The aim of this research was to review the scientific evidences among the immunological, nervous and endocrinesystems and its involvement and implication on sinovite rheumatoid. The elucidation of these mechanisms will permit the technological development oftherapies that suppress the stressors action, what will contribute largely on patients recovery and their life.