Postoperative pain and edema control following different protocols of preemptive analgesia in the surgical removal of impacted third molars: a triple-blind parallel randomized placebo-controlled clinical trial

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dc.creatorBianca Fernanda Espósito Santos
dc.creatorFernando de Oliveira Costa
dc.creatorAecio Abnar Campos Pinto Júnior
dc.creatorAndre Vitor Alves Araújo
dc.creatorRenata Magalhães Cyrino
dc.creatorLuis Otávio Miranda Cota
dc.date.accessioned2024-06-27T18:06:25Z
dc.date.accessioned2025-09-08T23:34:00Z
dc.date.available2024-06-27T18:06:25Z
dc.date.issued2021-08
dc.identifier.doihttps://doi.org/10.1016/j.jcms.2021.01.002
dc.identifier.issn1878-4119
dc.identifier.urihttps://hdl.handle.net/1843/69457
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgery
dc.rightsAcesso Restrito
dc.subjectAnalgesia
dc.subjectDexamethasone
dc.subjectIbuprofen
dc.subjectMolar
dc.subjectSurgery, oral
dc.subjectMolar, third
dc.subjectPain, postoperative
dc.subjectEdema
dc.subject.otherpreemptive analgesia
dc.subject.otherTHIRD MOLARS
dc.subject.otherpain acesso restritobusca dia 26/06/2024 Postoperative pain and edema control following different protocols of preemptive analgesia in the surgical removal of impacted third molars: a triple-blind parallel randomized placebo-controlled clinical trial ¿
dc.subject.otherClinical trials
dc.titlePostoperative pain and edema control following different protocols of preemptive analgesia in the surgical removal of impacted third molars: a triple-blind parallel randomized placebo-controlled clinical trial
dc.typeArtigo de periódico
local.citation.epage704
local.citation.issue8
local.citation.spage694
local.citation.volume49
local.description.resumoThis randomized controlled clinical trial aimed to evaluate the preemptive effects of acetaminophen, ibuprofen, ketoprofen, nimesulide or dexamethasone on postoperative pain and edema in the surgical removal of impacted third molars. Participants underwent bilateral surgeries at 2 different times and were randomly given the test drug or placebo (split-mouth). Postoperative pain, edema and rescue medication were evaluated at different times. Study power was >80% for the observed effect size in the crossover repeated measures design. Differences between test drug and placebo were the response variable. Generalized Estimation Equation models were adjusted for each outcome. Sample comprised 5 groups (n = 20 each). Ibuprofen and nimesulide showed higher overall effects on pain scores over time, with no differences between them (p = 0.557). Acetaminophen showed significantly lower overall effects in edema control over time, when compared to other test drugs, that showed similar effects. Lower quantity of rescue medication were also observed for ibuprofen and nimesulide, with no differences between them (p = 0.999). Ibuprofen and nimesulide showed beneficial overall preemptive effects. Hence, in the decision-making process for preemptive analgesia in impacted third molar surgeries, ibuprofen and nimesulide should be considered on a case-by-case basis as the drugs.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1010518221000056?via%3Dihub

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