Photobiomodulation drives pericyte mobilization towards skin regeneration

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dc.creatorIsabella Bittencourt do Valle
dc.creatorRafaela Férrer de Oliveira
dc.creatorLarissa Fassarela Marquiore
dc.creatorSoraia Macari
dc.creatorFlávio Almeida do Amaral
dc.creatorHumberto Jácome-santos
dc.creatorLucíola Silva Barcelos
dc.creatorGustavo Batista Menezes
dc.creatorMárcia Martins Marque
dc.creatorAlexander Birbrair
dc.creatorIvana Márcia Alves Diniz
dc.creatorPedro Henrique Dias Moura Prazeres
dc.creatorRicardo Alves Mesquita
dc.creatorTarcília Aparecida Silva
dc.creatorHortência Maciel de Castro Oliveira
dc.creatorPollyana Ribeiro Castro
dc.creatorIuri Dornelas Prates Freitas
dc.creatorSicília Rezende Oliveira
dc.creatorNatália Aparecida Gomes
dc.date.accessioned2022-12-22T15:44:10Z
dc.date.accessioned2025-09-09T00:09:21Z
dc.date.available2022-12-22T15:44:10Z
dc.date.issued2020-11-06
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1038/s41598-020-76243-7
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1843/48366
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.subjectWounds and injuries
dc.subjectCells
dc.subjectBlood
dc.subjectTissues
dc.titlePhotobiomodulation drives pericyte mobilization towards skin regeneration
dc.typeArtigo de periódico
local.citation.epage15
local.citation.issue1
local.citation.spage01
local.citation.volume10
local.description.resumoPhotobiomodulation is being widely applied for improving dermal or mucosal wound healing. However, the underlying cellular and molecular processes that directly contribute to its effects remain poorly understood. Pericytes are relevant cells involved in the wound microenvironment and could be one of the main targets of photobiomodulation due to their plasticity and perivascular localization. Herein, we investigate tissue repair under the photobiomodulation stimulus using a pericyte labeled (or reporter) transgenic mice. Using a model of two contralateral back wounds, one the control and the other photoactivated daily (660 nm, 20 mW, 0.71 W/cm2, 5 J/cm2, 7 s, 0.14 J), we showed an overall influx of immune and undifferentiated cells and higher mobilization of a potent pericyte subpopulation (Type-2 pericytes) in the photoactivated wounds in comparison to the controls. Doppler analysis showed a significant increase in the blood flow in the photoactivated wounds, while marked vascular supply was observed histologically. Histochemical analysis has indicated more advanced stages of tissue repair after photoactivation. These data suggest that photobiomodulation significantly accelerates tissue repair through its vascular effects with direct recruitment of pericytes to the injury site.
local.publisher.countryBrasil
local.publisher.departmentFAO - FACULDADE DE ODONTOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/s41598-020-76243-7

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