Seasonal variation of cell proliferation and apoptosis in the efferent ductules and epididymis of the Neotropical bat Artibeus lituratus (Chiroptera, Phyllostomidae)

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dc.creatorGabriel Henrique Campolina silva
dc.creatorRex A. Hess
dc.creatorCleida Aparecida de Oliveira
dc.date.accessioned2023-07-14T20:32:58Z
dc.date.accessioned2025-09-08T23:21:43Z
dc.date.available2023-07-14T20:32:58Z
dc.date.issued2019
dc.identifier.doihttps://doi.org/10.1016/j.ygcen.2018.02.003
dc.identifier.issn1095-6840
dc.identifier.urihttps://hdl.handle.net/1843/56298
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofGeneral and Comparative Endocrinology
dc.rightsAcesso Aberto
dc.subjectApoptose
dc.subjectMorcego
dc.subject.otherEfferent ductules
dc.subject.otherEpididymis
dc.subject.otherCell proliferation
dc.subject.otherApoptosis
dc.subject.otherSeasonality
dc.subject.otherChiroptera
dc.titleSeasonal variation of cell proliferation and apoptosis in the efferent ductules and epididymis of the Neotropical bat Artibeus lituratus (Chiroptera, Phyllostomidae)
dc.typeArtigo de periódico
local.citation.epage10
local.citation.spage3
local.citation.volume273
local.description.resumoThebalance between cell proliferation and apoptosis is important for maintenance of male fertility, being influenced by a variety of stimuli including androgens and estrogens. However, studies concerning regulation of these processes along the male reproductive tract under physiological conditions are scarce. Therefore, in this study, we investigated the profile of cell proliferation and apoptosis in the efferent ductules and epididymis of the Neotropical bat Artibeus lituratus, a seasonal breeder that presents natural variation in components of the androgen and estrogen responsive systems along the circannual cycle. Low rates of cell proliferation and apoptosis were found in the efferent ductules and epididymis of A. lituratus during the reproductive period, as few epithelial cells were positive for MCM7 (proliferation marker) and cleaved caspase-3 or TUNEL (apoptosis markers). In contrast, during the regressive period, the rate of both proliferating and apoptotic cells was significantly higher in the epithelium lining the efferent ductules as well as throughout the epididymis. The increased proliferative activity at this phase was positively correlated with the expression of estrogen receptor alpha (ERa), whereas the variation in apoptosis appears to be unrelated to the local expression of androgen and estrogen receptors. Together, these data suggest that cell proliferation and apoptosis are differentially modulated in the efferent ductules and epididymis of A. lituratus during the annual reproductive cycle, and support the hypothesis that ERa may be important in preparing the male reproductive tract for sexual recrudescence.
local.identifier.orcidhttps://orcid.org/0000-0002-4473-3340
local.identifier.orcidhttps://orcid.org/0000-0003-2649-3563
local.identifier.orcidhttps://orcid.org/0000-0001-9610-7846
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0016648017308766?via%3Dihub

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