Performance of new biomarkers of nephropathy in patients with type 1 diabetes mellitus

Página do item simplificado
dc.creatorManuelle Maria Pereira Natividade
dc.creatorCaroline Pereira Domingueti
dc.creatorAna Paula Salles Moura Fernandes
dc.creatorRodrigo Bastos Fóscolo
dc.creatorJanice Sepúlveda Reis
dc.creatorLuci Maria SantAna Dusse
dc.creatorCamila Stefanie Fonseca de Oliveira
dc.creatorJoão Paulo Amaral Haddad
dc.creatorLara Carvalho Godoi
dc.creatorKarina Braga Gomes Borges
dc.creatorHenrique Pimenta Barroso Magalhães
dc.date.accessioned2022-03-21T16:05:09Z
dc.date.accessioned2025-09-09T00:00:34Z
dc.date.available2022-03-21T16:05:09Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.9734/BJMMR/2016/23476
dc.identifier.issn2231-0614
dc.identifier.urihttps://hdl.handle.net/1843/40274
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBritish Journal of Medicine and Medical Research
dc.rightsAcesso Aberto
dc.subjectNefropatias diabéticas
dc.subjectDiabetes mellitus
dc.subjectCistatina C
dc.subjectFosfatase alcalina
dc.subjectGama-glutamiltransferase
dc.subject.otherDiabetic nephropathy
dc.subject.otherCystatin C
dc.subject.otherAlkaline phosphatase
dc.subject.otherGamma-glutamyl transferase
dc.titlePerformance of new biomarkers of nephropathy in patients with type 1 diabetes mellitus
dc.typeArtigo de periódico
local.citation.epage14
local.citation.issue3
local.citation.spage1
local.citation.volume15
local.description.resumoIntroduction: It is known that laboratorial tests (urinary albumin excretion and glomerular filtration rate), routinely used for nephropathy diagnosis in type 1 diabetes (T1DM), have limitations that justify the evaluation of new renal biomarkers. This study assessed the performance of cystatin C, alkaline phosphatase (AP) and gamma-glutamyl transferase (GGT) for nephropathy diagnosis in T1DM patients. The reduction of economic cost and increase in sensibility and specificity from correct biochemical diagnosis of diabetic nephropathy is an important objective of this work. Methods: Cystatin C, AP and GGT were determined in plasma and urine of healthy individuals (N=35) and T1DM patients with (N=45) and without nephropathy (N=80). Results: The plasma levels of cystatin C, AP and GGT, as well as urinary levels of cystatin C and AP were able to differentiate diabetic patients with and without nephropathy. Plasma cystatin C better followed the progression of albuminuria. Cystatin C and AP discriminated the onset of nephropathy in T1DM patients better than creatinine. AP plasma/urine ratio progressively increased from the controls to the diabetic patients without and with nephropathy. Conclusion: The plasma levels of cystatin C and AP may be useful, with the classical markers of renal function, for nephropathy diagnosis and monitoring in T1DM patients.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.journaljammr.com/index.php/JAMMR/article/view/10278

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Performance of new biomarkers of nephropathy inpatients withtype 1 Diabetes mellitus.pdf
Tamanho:
310.74 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG