Non-alcoholic fatty liver disease in premenopausal women with polycystic ovary syndrome: a systematic review and meta-analysis

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dc.creatorAna Luiza Lunardi Rocha
dc.creatorL. C. Faria
dc.creatorT. C. M. Guimarães
dc.creatorGiovanna Vieira Moreira
dc.creatorA. L. Cândido
dc.creatorC. A. Couto
dc.creatorFernando Marcos dos Reis
dc.date.accessioned2023-07-19T18:12:27Z
dc.date.accessioned2025-09-09T00:18:21Z
dc.date.available2023-07-19T18:12:27Z
dc.date.issued2017
dc.identifier.doihttps://doi.org/10.1007/s40618-017-0708-9
dc.identifier.issn1720-8386
dc.identifier.urihttps://hdl.handle.net/1843/56740
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Endocrinological Investigation
dc.rightsAcesso Restrito
dc.subjectObesidade
dc.subjectDiabetes
dc.subjectResistência à insulina
dc.subjectSíndrome metabólica
dc.subject.otherNon-alcoholic fatty liver disease (NAFLD)
dc.subject.otherObesity
dc.subject.otherDiabetes mellitus
dc.subject.otherInsulin resistance
dc.subject.otherMetabolic syndrome
dc.titleNon-alcoholic fatty liver disease in premenopausal women with polycystic ovary syndrome: a systematic review and meta-analysis
dc.typeArtigo de periódico
local.citation.epage1288
local.citation.spage1279
local.citation.volume40
local.description.resumoPurpose Non-alcoholic fatty liver disease (NAFLD) is an insidious pathologic condition that can manifest from simple steatosis to steatohepatitis (NASH) with potential progression to cirrhosis. Like the polycystic ovary syndrome (PCOS), NAFLD is associated with obesity, diabetes mellitus, insulin resistance and metabolic syndrome. PCOS women have an increased risk of NAFLD, but it is debatable which features of PCOS, either specific (androgen excess) or unspecific (metabolic derangements) affect the NAFLD risk. Methods We performed a systematic review and meta-analysis of studies that addressed the association of PCOS and NAFLD. We selected 17 studies published between 2007 and 2017 that included 2734 PCOS patients and 2561 controls of similar age and body mass index (BMI). Results PCOS patients have increased prevalence of NAFLD (odds ratio 2.54, 95% confidence interval 2.19–2.95). PCOS women with hyperandrogenism (classic phenotype) have a higher prevalence of NAFLD compared to women with PCOS without hyperandrogenism, even after correction for confounding variables. Among women with PCOS, those with NAFLD have higher serum total testosterone (mean difference 0.40 nmol/L, 95% CI 0.29–0.50 nmol/L) and free androgen index (mean difference 4.46, 95% CI 3.53–5.39) than those without NAFLD. The studies that used multivariate analysis controlling for age, BMI, triglycerides, and insulin resistance index confirmed that serum androgens are independent predictors of NAFLD in women with PCOS. Conclusion The prevalence of NAFLD is increased in women with PCOS and the presence of NAFLD is associated with high serum androgen levels, in addition to obesity and insulin resistance.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s40618-017-0708-9

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