Potential drug interactions in drug therapy prescribed for older adults at hospital discharge: cross-sectional study.

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dc.creatorBianca Menezes Dias
dc.creatorFabiana Silvestre dos Santos
dc.creatorAdriano Max Moreira Reis
dc.date.accessioned2024-07-12T18:01:48Z
dc.date.accessioned2025-09-08T23:43:15Z
dc.date.available2024-07-12T18:01:48Z
dc.date.issued2019-08
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1516-3180.2019.013405072019
dc.identifier.issn1806-9460
dc.identifier.urihttps://hdl.handle.net/1843/70454
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofSao Paulo Medical Journal
dc.rightsAcesso Aberto
dc.subjectInterações medicamentosas
dc.subjectIdoso fragilizado
dc.subjectAlta do paciente
dc.subjectTerapia medicamentosa
dc.subject.otherDrug interactions
dc.subject.otherFrail elderly
dc.subject.otherPatient discharge
dc.subject.otherDrug therapy
dc.titlePotential drug interactions in drug therapy prescribed for older adults at hospital discharge: cross-sectional study.
dc.typeArtigo de periódico
local.citation.epage378
local.citation.issue4
local.citation.spage369
local.citation.volume137
local.description.resumoBACKGROUND: Older adults with a range of comorbidities are often prescribed multiple medications, which favors drug interactions. OBJECTIVES: To establish the frequency of potential drug interactions in prescriptions at hospital discharge among older adults and to identify the associated factors. DESIGN AND SETTING: Cross-sectional study conducted in a public hospital. METHODS: An initial face-to-face interview, data collection from the electronic medical records (covering sociodemographic, clinical, functional and drug therapy-related variables) and telephone follow-up after discharge were conducted to confirm the medication prescribed at discharge. Drug interactions were identified through the Micromedex DrugReax software, along with interactions that should be avoided among the elderly, as per the 2015 American Geriatric Society/Beers criteria. Multivariable logistic regression was performed. RESULTS: Potential for drug interactions was identified in the discharge drug therapy of 67.8% of the 255 older adults evaluated (n = 172), and 54.5% (n = 145) of the drug interactions were major. Among the drug interactions that should be avoided among older adults, those that increase the risk of falls were the most frequent. The drug interactions thus identified were independently associated with polypharmacy (odds ratio, OR = 12.62; 95% confidence interval, CI 6.25-25.50; P = 0.00), diabetes mellitus (OR = 2.16; 95% CI 1.05-4.44; P = 0.04), hypothyroidism (OR = 7.29; 95% CI 2.03-26.10; P = 0.00), chronic kidney disease (OR = 3.41; 95% CI 1.09-10.64; P = 0.03) and hospitalization in geriatric units (OR = 0.45; 95% CI 0.22-0.89; P = 0.02). CONCLUSION: The frequency of potential drug interactions in drug therapy prescribed at discharge for these older adults was high. Polypharmacy, diabetes mellitus, hypothyroidism and chronic kidney disease were positively associated with occurrences of drug interactions, while hospitalization in geriatric units showed an inverse association.
local.identifier.orcidhttps://orcid.org/0000-0002-8842-3643
local.identifier.orcidhttps://orcid.org/0000-0002-6551-4403
local.identifier.orcidhttps://orcid.org/0000-0002-0017-7338
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/spmj/a/LThYwWW8TnK8JTC8sBV3c4w#

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