The challenge of evaluating adnexal masses in breast cancer patients

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dc.creatorTomás Reinert
dc.creatorAngélica Nogueira Rodrigues
dc.creatorFabiola Procacci Kestelman
dc.creatorPatricia Ashton-Prolla
dc.creatorMárcia Silveira Graudenz
dc.creatorJosé Bines
dc.date.accessioned2023-08-11T21:01:08Z
dc.date.accessioned2025-09-09T01:19:54Z
dc.date.available2023-08-11T21:01:08Z
dc.date.issued2018-03-12
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.clbc.2018.03.006
dc.identifier.issn1526-8209
dc.identifier.urihttps://hdl.handle.net/1843/57772
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinical Breast Cancer
dc.rightsAcesso Restrito
dc.subjectNeoplasias Ovarianas
dc.subjectNeoplasias da Mama
dc.subjectMarcadores tumorais
dc.subject.otherBRCA mutation
dc.subject.otherBreast neoplasms
dc.subject.otherOvarian Neoplasms
dc.subject.otherBiomarkers, Tumor
dc.titleThe challenge of evaluating adnexal masses in breast cancer patients
dc.typeArtigo de periódico
local.citation.epagee-94
local.citation.issue4
local.citation.spagee-87
local.citation.volume18
local.description.resumoThis narrative literature review addresses the problem of an adnexal mass discovered during the course of breast cancer (BC) care, which may represent a benign condition, a metastatic process, or a primary ovarian cancer (OC),clinical scenarios associated with distinct physiopathology and prognosis. Furthermore, the coexistence of BC and OC in the same patient may be owing to a hereditary disorder, deserving specific management strategies and counseling. The initial detection and evaluation of an adnexal mass in a patient with BC requires a high index of suspicion, and the initial workup should include a thorough medical history and physical examination, measurement of tumor markers, complete blood count, and imaging tests. Transvaginal ultrasonography remains the standard tool, and findings suggestive of malignancy include bilateral tumors, thick septations, predominance of a solid component,Doppler flow to the solid component, and ascites. From the pathology point of view, features that are suggestive of metastatic disease include bilaterality, mild ovarian enlargement, vascular emboli, no omental deposits, and the absence of transition from benign to malignant epithelium. Although there is a considerable overlap in OC and BC immunohistochemical profiles, BC usually stain positive for GCDFP-15 and negative for vimentine, PAX8, and WT1, and OC often stain positive for CK7, PAX8, WT1, and to mesothelin. Genetic counselling should always be indicated in this clinical scenario. In conclusion, diagnostic spectrum of an ovarian mass in a patient with BC is broad, and a systematic multi-professional strategy is necessary to conduct these challenging cases.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1526820918300260?via%3Dihub

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