Immune activation and bacterial translocation: a link between impaired immune recovery and frequent visceral leishmaniasis relapses in HIV-infected patients

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dc.creatorMaria Lucianasilva-freitas
dc.creatorGlaucia Fernandes Cota
dc.creatorTalia s. Machado-de-assis
dc.creatorCarmem Giacoia-gripp
dc.creatorAna Rabello
dc.creatorAlda m. Da-cruz
dc.creatorJoanna r. Santos-oliveira
dc.creatorFarhat Afrin
dc.date.accessioned2024-11-27T23:54:20Z
dc.date.accessioned2025-09-09T00:13:19Z
dc.date.available2024-11-27T23:54:20Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doi10.1371/journal.pone.0167512
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1843/78332
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPlos One
dc.subjectLeishmaniose Visceral
dc.subjectHIV
dc.subjectPacientes
dc.titleImmune activation and bacterial translocation: a link between impaired immune recovery and frequent visceral leishmaniasis relapses in HIV-infected patients
dc.typeArtigo de periódico
local.citation.epage18
local.citation.issue12
local.citation.spage1
local.citation.volume11
local.description.resumoThe maintenance of chronic immune activation due to leishmaniasis or even due to microbial translocation is associated with immunosenescence and may contribute to frequent relapses. Our aim was to investigate whether patients with HIV-associated visceral leishmaniasis (VL/HIV) who experience a single episode of VL have different immunological behaviors in comparison to those who experience frequent relapses. VL/HIV patients were allocated to non-relapsing (NR, n = 6) and relapsing (R, n = 11) groups and were followed from the active phase of VL up to 12 months post-treatment (mpt). The patients were receiving highly active antiretroviral therapy (HAART) and secondary prophylaxis after VL therapy. During active VL, the two groups were similar in all immunological parameters, including the parasite load. At 6 and 12 mpt, the NR group showed a significant gain of CD4+ T cells, a reduction of lymphocyte activation, and lower soluble CD14 and anti-Leishmania IgG3 levels compared to the R group. The viral load remained low, without correlation with the activation. The two groups showed elevated but similar percentages of senescent T cells. These findings suggest a decreased ability of the R group to downmodulate immune activation compared to the NR group. Such functional impairment of the effector response may be a useful indicator for predicting clinical prognosis and recommending starting or stopping secondary prophylaxis.
local.publisher.countryBrasil
local.publisher.departmentMEDICINA - FACULDADE DE MEDICINA
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167512

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