Late-relapsing hepatitis after yellow fever

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dc.creatorIzabela Maurício Rezende
dc.creatorLeonardo Soares Pereira
dc.creatorJordana Rodrigues Barbosa Fradico
dc.creatorMarcelo Antônio Pascoal Xavier
dc.creatorPedro Augusto Alves
dc.creatorAna Carolina Campi-Azevedo
dc.creatorElaine Speziali
dc.creatorLívia Zignago Moreira dos Santos
dc.creatorNatalia Soares Albuquerque
dc.creatorIndiara Penido
dc.creatorTayrine Araujo Santos
dc.creatorAna Paula Dinis Ano Bom
dc.creatorAndrea Marques Vieira da Silva
dc.creatorCamilla Bayma Fernandes
dc.creatorCarlos Eduardo Calzavara
dc.creatorErna Geessien Kroon
dc.creatorOlindo Assis Martins-Filho
dc.creatorAndréa Teixeira-Carvalho
dc.creatorBetânia Paiva Drumond
dc.date.accessioned2025-02-11T21:12:51Z
dc.date.accessioned2025-09-09T00:57:36Z
dc.date.available2025-02-11T21:12:51Z
dc.date.issued2020-02-17
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/v12020222
dc.identifier.issn1999-4915
dc.identifier.urihttps://hdl.handle.net/1843/79929
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofViruses
dc.rightsAcesso Aberto
dc.subjectVírus da Febre Amarela
dc.subjectHepatite
dc.subjectFlavivirus
dc.subject.otherYellow Fever virus
dc.subject.otherYellow Fever
dc.subject.otherLiver demage
dc.subject.otherViral persisntece
dc.subject.otherHepatitis
dc.subject.otherLiver biopsy
dc.subject.otherPersistent infection
dc.subject.otherRelapsing hepatitis
dc.subject.otherEmerging virus
dc.titleLate-relapsing hepatitis after yellow fever
dc.typeArtigo de periódico
local.citation.epage9
local.citation.issue2
local.citation.spage1
local.citation.volume12
local.description.resumoOne patient presented hyporexia, asthenia, adynamia, and jaundice two months after acute yellow fever (YF) onset; plus laboratory tests indicating hepatic cytolysis and a rebound of alanine and aspartate transaminases, and total and direct bilirubin levels. Laboratory tests discarded autoimmune hepatitis, inflammatory or metabolic liver disease, and new infections caused by hepatotropic agents. Anti-YFV IgM, IgG and neutralizing antibodies were detected in different times, but no viremia. A liver biopsy was collected three months after YF onset and tested positive for YFV antigens and wild-type YFV-RNA (364 RNA-copies/gram/liver). Transaminases and bilirubin levels remained elevated for five months, and the arresting of symptoms persisted for six months after the acute YF onset. Several serum chemokines, cytokines, and growth factors were measured. A similar immune response profile was observed in the earlier phases of the disease, followed by more pronounced changes in the later stages, when transaminases levels returned to normal. The results indicated viral persistence in the liver and continual liver cell damage three months after YF onset and reinforced the need for extended follow-ups of YF patients. Further studies to investigate the role of possible viral persistence and the immune response causing relapsing hepatitis following YF are also necessary.
local.identifier.orcidhttps://orcid.org/0000-0003-2616-6300
local.identifier.orcidhttps://orcid.org/0000-0002-5426-0655
local.identifier.orcidhttps://orcid.org/0000-0002-9081-1493
local.identifier.orcidhttps://orcid.org/0000-0002-9659-5621
local.identifier.orcidhttps://orcid.org/0000-0001-6306-3605
local.identifier.orcidhttps://orcid.org/0000-0002-2410-3915
local.identifier.orcidhttps://orcid.org/0000-0001-7135-8227
local.identifier.orcidhttps://orcid.org/0000-0002-2299-0792
local.identifier.orcidhttps://orcid.org/0000-0003-4566-2545
local.identifier.orcidhttps://orcid.org/0000-0003-2721-3826
local.identifier.orcidhttps://orcid.org/0000-0002-5494-4889
local.identifier.orcidhttps://orcid.org/0000-0003-2814-5183
local.identifier.orcidhttps://orcid.org/0000-0002-4049-4055
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/1999-4915/12/2/222

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