Gallic acid modulates phenotypic behavior and gene expression in oral squamous cell carcinoma cells by interfering with leptin pathway

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dc.creatorEliane Macedo Sobrinho Santos
dc.creatorRogério Gonçalves da Rocha
dc.creatorHércules Otacílio Santos
dc.creatorTalita Antunes Guimarães
dc.creatorCarlos Alberto de Carvalho Fraga
dc.creatorLuiz Henrique da Silveira
dc.creatorPaulo Ricardo Batista
dc.creatorPaulo Sérgio Lopes de Oliveira
dc.creatorGeraldo Aclécio Melo
dc.creatorSérgio Henrique Sousa Santos
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.creatorLucyana Conceição Farias
dc.date.accessioned2022-08-23T13:35:05Z
dc.date.accessioned2025-09-09T00:43:58Z
dc.date.available2022-08-23T13:35:05Z
dc.date.issued2018-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1016/j.prp.2017.11.022
dc.identifier.issn0344-0338
dc.identifier.urihttps://hdl.handle.net/1843/44484
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPathology: Research and Practice
dc.rightsAcesso Aberto
dc.subjectÁcido gálico
dc.subjectCarcinoma de células escamosas
dc.subjectCélulas - Proliferação
dc.subjectMigração celular
dc.subjectNeovascularização
dc.subjectApoptose
dc.titleGallic acid modulates phenotypic behavior and gene expression in oral squamous cell carcinoma cells by interfering with leptin pathway
dc.typeArtigo de periódico
local.citation.epage37
local.citation.issue1
local.citation.spage30
local.citation.volume214
local.description.resumoGallic acid is a polyphenolic compost appointed to interfere with neoplastic cells behavior. Evidence suggests an important role of leptin in carcinogenesis pathways, inducing a proliferative phenotype. We investigated the potential of gallic acid to modulate leptin-induced cell proliferation and migration of oral squamous cell carcinoma cell lines. The gallic acid effect on leptin secretion by oral squamous cell carcinoma cells, as well as the underlying molecular mechanisms, was also assessed. For this, we performed proliferation, migration, immunocytochemical and qPCR assays. The expression levels of cell migration-related genes (MMP2, MMP9, Col1A1, and E-cadherin), angiogenesis (HIF-1α, mir210), leptin signaling (LepR, p44/42 MAPK), apoptosis (casp-3), and secreted leptin levels by oral squamous cell carcinoma cells were also measured. Gallic acid decreased proliferation and migration of leptin-treated oral squamous cell carcinoma cells, and reduced mRNA expression of MMP2, MMP9, Col1A1, mir210, but did not change HIF-1α. Gallic acid decreased levels of leptin secreted by oral squamous cell carcinoma cells, accordingly with downregulation of p44/42 MAPK expression. Thus, gallic acid appears to break down neoplastic phenotype of oral squamous cell carcinoma cells by interfering with leptin pathway.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0344033817301978?via%3Dihub

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