Emergence of the Asian lineage of Zika virus in Angola: an outbreak investigation

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dc.creatorSarah Hill
dc.creatorAna Luísa Micolo Cândido
dc.creatorFilipa Vaz
dc.creatorCruz dos Santos Sebastião
dc.creatorChieh-Hsi Wu
dc.creatorMoritz U. G. Kraemer
dc.creatorAdriana Melo
dc.creatorBruno Luiz Fonseca Schamber-Reis
dc.creatorGirlene S. de Azevedo
dc.creatorAmilcar Tanuri
dc.creatorLuiza Higa
dc.creatorJocelyne Vasconcelos
dc.creatorCarina Clemente
dc.creatorSara Pereira da Silva
dc.creatorDarlan da Silva Candido
dc.creatorIngra Claro
dc.creatorDomingos Quibuco
dc.creatorCristóvão Domingos
dc.creatorBárbara Pocongo
dc.creatorAlexander Watts
dc.creatorKamran Khan
dc.creatorLuiz Carlos Junior Alcantara
dc.creatorZoraima Neto
dc.creatorEster C. Sabino
dc.creatorEve Lackritz
dc.creatorOliver Pybus
dc.creatorMaria João Alves
dc.creatorJoana Afonso
dc.creatorNuno R. Faria
dc.creatorDomingos Jandondo
dc.creatorLíbia Zé-zé
dc.creatorRenato Santana de Aguiar
dc.creatorJoilson Xavier
dc.creatorJulien Thézé
dc.creatorMarinela Mirandela
dc.date.accessioned2023-07-17T18:02:10Z
dc.date.accessioned2025-09-08T23:57:46Z
dc.date.available2023-07-17T18:02:10Z
dc.date.issued2019
dc.identifier.doihttps://doi.org/10.1016/S1473-3099(19)30293-2
dc.identifier.issn1473-3099
dc.identifier.urihttps://hdl.handle.net/1843/56414
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofThe Lancet: Infectious Diseases
dc.rightsAcesso Aberto
dc.subjectVírus da Zika
dc.subjectÁfrica
dc.subject.otherZika
dc.subject.otherAfrica
dc.titleEmergence of the Asian lineage of Zika virus in Angola: an outbreak investigation
dc.typeArtigo de periódico
local.citation.epage1147
local.citation.issue10
local.citation.spage1138
local.citation.volume19
local.description.resumoBackground Zika virus infections and suspected microcephaly cases have been reported in Angola since late 2016, but no data are available about the origins, epidemiology, and diversity of the virus. We aimed to investigate the emergence and circulation of Zika virus in Angola. Methods Diagnostic samples collected by the Angolan Ministry of Health as part of routine arboviral surveillance were tested by real-time reverse transcription PCR by the Instituto Nacional de Investigação em Saúde (Ministry of Health, Luanda, Angola). To identify further samples positive for Zika virus and appropriate for genomic sequencing, we also tested samples from a 2017 study of people with HIV in Luanda. Portable sequencing was used to generate Angolan Zika virus genome sequences from three people positive for Zika virus infection by real-time reverse transcription PCR, including one neonate with microcephaly. Genetic and mobility data were analysed to investigate the date of introduction and geographical origin of Zika virus in Angola. Brain CT and MRI, and serological assays were done on a child with microcephaly to confirm microcephaly and assess previous Zika virus infection. Findings Serum samples from 54 people with suspected acute Zika virus infection, 76 infants with suspected microcephaly, 24 mothers of infants with suspected microcephaly, 336 patients with suspected dengue virus or chikungunya virus infection, and 349 samples from the HIV study were tested by real-time reverse transcription PCR. Four cases identified between December, 2016, and June, 2017, tested positive for Zika virus. Analyses of viral genomic and human mobility data suggest that Zika virus was probably introduced to Angola from Brazil between July, 2015, and June, 2016. This introduction probably initiated local circulation of Zika virus in Angola that continued until at least June, 2017. The infant with microcephaly in whom CT and MRI were done had brain abnormalities consistent with congenital Zika syndrome and serological evidence for Zika virus infection. Interpretation Our analyses show that autochthonous transmission of the Asian lineage of Zika virus has taken place in Africa. Zika virus surveillance and surveillance of associated cases of microcephaly throughout the continent is crucial. Funding Royal Society, Wellcome Trust, Global Challenges Research Fund (UK Research and Innovation), Africa Oxford, John Fell Fund, Oxford Martin School, European Research Council, Departamento de Ciência e Tecnologia/Ministério da Saúde/National Council for Scientific and Technological Development, and Ministério da Educação/Coordenação de Aperfeicoamento de Pessoal de Nível Superior.
local.identifier.orcidhttps://orcid.org/0000-0002-2995-2596
local.identifier.orcidhttps://orcid.org/0000-0003-1232-0119
local.identifier.orcidhttps://orcid.org/0000-0001-9386-725X
local.identifier.orcidhttps://orcid.org/0000-0002-0814-6931
local.identifier.orcidhttps://orcid.org/0000-0002-7640-1463
local.identifier.orcidhttps://orcid.org/0000-0003-2622-534X
local.identifier.orcidhttps://orcid.org/0000-0002-7318-693X
local.identifier.orcidhttps://orcid.org/0000-0002-5080-3130
local.identifier.orcidhttps://orcid.org/0000-0001-8637-2910
local.identifier.orcidhttps://orcid.org/0000-0003-3480-582X
local.identifier.orcidhttps://orcid.org/0000-0003-0852-0492
local.identifier.orcidhttps://orcid.org/0000-0002-5397-7291
local.identifier.orcidhttps://orcid.org/0000-0002-8797-2667
local.identifier.orcidhttps://orcid.org/0000-0001-6943-7890
local.identifier.orcidhttps://orcid.org/0000-0001-7258-1439
local.identifier.orcidhttps://orcid.org/0000-0001-5180-3717
local.identifier.orcidhttps://orcid.org/0000-0003-3916-2018
local.identifier.orcidhttps://orcid.org/0000-0001-8188-9494
local.identifier.orcidhttps://orcid.org/0000-0001-8847-4136
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1473309919302932?via%3Dihub

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