Prolonged dipyridamole administration reduces myocardial perfusion defects in experimental chronic Chagas cardiomyopathy

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dc.creatorDenise Mayumi Tanaka
dc.creatorLuciano Fonseca Lemos de Oliveira
dc.creatorJosé Antonio Marin Neto
dc.creatorMinna Moreira Dias Romano
dc.creatorEduardo Elias Vieira de Carvalho
dc.creatorAntonio Carlos Leite de Barros Filho
dc.creatorFernando Fonseca França Ribeiro
dc.creatorJorge Mejia Cabeza
dc.creatorCarla Duque Lopes
dc.creatorCamila Godoy Fabricio
dc.creatorNorival Kesper
dc.creatorHenrique Turin Moreira
dc.creatorLauro Wichert Ana
dc.creatorAndré Schmidt
dc.creatorMaria de Lourdes Higuchi
dc.creatorEdecio Cunha Neto
dc.creatorMarcus Vinícius Simões
dc.date.accessioned2022-05-09T14:33:07Z
dc.date.accessioned2025-09-09T00:38:09Z
dc.date.available2022-05-09T14:33:07Z
dc.date.issued2019-09
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1007/s12350-018-1198-7
dc.identifier.issn1532-6551
dc.identifier.urihttps://hdl.handle.net/1843/41477
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Nuclear Cardiology
dc.rightsAcesso Restrito
dc.subjectCardiomiopatia chagásica
dc.subjectMicrocirculação
dc.subjectCirculação coronária
dc.subjectAnimais de laboratório
dc.subjectDisfunção ventricular
dc.subject.otherChagas cardiomyopathy
dc.subject.otherCoronary microcirculation
dc.subject.otherDipyridamole
dc.subject.otherHamsters
dc.subject.otherVentricular dysfunction
dc.titleProlonged dipyridamole administration reduces myocardial perfusion defects in experimental chronic Chagas cardiomyopathy
dc.typeArtigo de periódico
local.citation.epage1579
local.citation.issue5
local.citation.spage1569
local.citation.volume26
local.description.resumoBackground: Myocardial perfusion defects (MPD) due to coronary microvascular dysfunction is frequent in chronic Chagas cardiomyopathy (CCC) and may be involved with development of myocardial damage. We investigated whether MPD precedes left ventricular systolic dysfunction and tested the hypothesis that prolonged use of dipyridamole (DIPY) could reduce MPD in an experimental model of CCC in hamsters. Methods and results: We investigated female hamsters 6-months after T. cruzi infection (baseline condition) and control animals, divided into T. cruzi-infected animals treated with DIPY (CH + DIPY) or placebo (CH + PLB); and uninfected animals treated with DIPY (CO + DIPY) or placebo (CO + PLB). The animals were submitted to echocardiogram and rest SPECT-Sestamibi-Tc99m myocardial perfusion scintigraphy. Next, the animals were treated with DIPY (4 mg/kg bid, intraperitoneal) or saline for 30 days, and reevaluated with the same imaging methods. At baseline, the CH + PLB and CH + DIPY groups showed larger areas of perfusion defect (13.2 ± 13.2% and 17.3 ± 13.2%, respectively) compared with CO + PLB and CO + DIPY (3.8 ± 2.2% e 3.5 ± 2.7%, respectively), P < .05. After treatment, we observed: reduction of perfusion defects only in the CH + DIPY group (17.3 ± 13.2% to 6.8 ± 7.6%, P = .001) and reduction of LVEF in CH + DIPY and CH + PLB groups (from 65.3 ± 9.0% to 53.6 ± 6.9% and from 69.3 ± 5.0% to 54.4 ± 8.6%, respectively, P < .001). Quantitative histology revealed greater extents of inflammation and interstitial fibrosis in both Chagas groups, compared with control group (P < .001), but no difference between Chagas groups (P > .05). Conclusions: The prolonged use of DIPY in this experimental model of CCC has reduced the rest myocardial perfusion defects, supporting the notion that those areas correspond to viable hypoperfused myocardium.
local.identifier.orcidhttps://orcid.org/ 0000-0002-5035-9172
local.identifier.orcidhttps://orcid.org/0000-0003-3455-2463
local.identifier.orcidhttp://orcid.org/0000-0002-8651-8833
local.identifier.orcidhttps://orcid.org/ 0000-0002-2526-0656
local.identifier.orcidhttp://orcid.org/0000-0001-5026-335X
local.identifier.orcidhttps://orcid.org/ 0000-0002-1182-4668
local.identifier.orcidhttps://orcid.org/ 0000-0003-0702-5043
local.identifier.orcidhttps://orcid.org/ 0000-0001-6174-6939
local.identifier.orcidhttps://orcid.org/ 0000-0003-4076-0461
local.identifier.orcidhttps://orcid.org/ 0000-0002-4543-4684
local.identifier.orcidhttps://orcid.org/ 0000-0003-2059-5120
local.identifier.orcidhttps://orcid.org/ 0000-0002-1090-8165
local.identifier.orcidhttps://orcid.org/ 0000-0002-1673-6456
local.identifier.orcidhttps://orcid.org/ 0000-0002-3699-3345
local.identifier.orcidhttps://orcid.org/ 0000-0001-6553-8387
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s12350-018-1198-7

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