Biocompatibility assessment of fibrous nanomaterials in mammalian embryos

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dc.creatorMichele Munk Pereira
dc.creatorHumberto de Mello Brandão
dc.creatorLuiz Sérgio de Almeida Camargo
dc.creatorCarolina Capobiango Romano Quintão
dc.creatorSaulo R. Silva
dc.creatorEliza Diniz de Souza
dc.creatorNádia Rezende Barbosa Raposo
dc.creatorJosé Manoel Marconcini
dc.creatorAdo Jorio de Vasconcelos
dc.creatorLuiz Orlando Ladeira
dc.date.accessioned2022-05-30T16:25:18Z
dc.date.accessioned2025-09-09T01:21:32Z
dc.date.available2022-05-30T16:25:18Z
dc.date.issued2016
dc.identifier.doi10.1016/j.nano.2016.01.006
dc.identifier.issn1549-9634
dc.identifier.urihttps://hdl.handle.net/1843/42073
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNanomedicine: Nanotechnology, Biology and Medicine
dc.rightsAcesso Restrito
dc.subjectNanomateriais
dc.subjectBiocompatibilidade
dc.subjectApoptose
dc.subject.otherFibrous nanomaterials
dc.subject.otherBiocompatibility
dc.subject.otherGene expression
dc.subject.otherApoptosis
dc.titleBiocompatibility assessment of fibrous nanomaterials in mammalian embryos
dc.typeArtigo de periódico
local.citation.epage1159
local.citation.issue5
local.citation.spage1151
local.citation.volume12
local.description.resumoCurrently there is a growing interest in the use of nanotechnology in reproductive medicine and reproductive biology. However, their toxic effects on mammalian embryos remain poorly understood. In this work, we evaluate the biocompatibility of two fibrous nanomaterials (NMs): cotton cellulose nanofibers (CNF) and carboxylated multiwalled carbon nanotubes (MWCNT-COOH), by performing an investigation of the embryonic development, gene expression (biomarkers focused on cell stress, apoptosis and totipotency) and in situ apoptosis in bovine embryos. Exposure to NMs did not interfere in preimplantation development or in the incidence of apoptosis in the bovine embryo, but they did affect the gene expression. The results presented are important for an understanding of the toxicity of cotton CNF and MWCNT-COOH on mammalian embryos. To our knowledge, we report the first evaluation of biocompatibility between these NMs on preimplantation embryos, which may open a new window for reproductive biomedical applications.
local.identifier.orcidhttps://orcid.org/0000-0001-8927-6190
local.identifier.orcidhttps://orcid.org/0000-0002-7405-3928
local.identifier.orcidhttps://orcid.org/0000-0001-9974-711X
local.identifier.orcidhttps://orcid.org/0000-0002-6232-2174
local.identifier.orcidhttps://orcid.org/0000-0001-5271-1048
local.identifier.orcidhttps://orcid.org/0000-0002-0419-9796
local.identifier.orcidhttps://orcid.org/0000-0002-5978-2735
local.identifier.orcidhttps://orcid.org/0000-0002-4935-6070
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1549963416000769?via%3Dihub

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