Potent antihypertensive effect of hancornia speciosa leaves extract.
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Background: Hancornia speciosa Gomes is an herb traditionally used in Brazil for blood pressure control.
Purpose: The present work investigated the antihypertensive effect of an extract from Hancornia speciosa
leaves (SFH) and analyzed its underlying mechanisms of action.
Methods: Hypertension was induced in mice by surgical removal of a kidney and by subcutaneous admin-
istration of a pellet with deoxycorticosterone. Vasodilatation was measured in mesenteric arteries with
a wire myograph. Nitrites were measured by fluorescence with 2,3-diaminonaphthalene and H2O2 was
measured with carbon microsensors.
Results: SFH (0.03, 0.1 or 1 mg/kg; po) induced a dose-dependent, long-lasting reduction in the sys-
tolic blood pressure in conscious DOCA-salt hypertensive mice (DOCA). Administration of SFH produced
a significant increase in the plasmatic level of nitrites. The systemic inhibition of nitric oxide synthase
by L-NAME (20 mg/kg) reduced its antihypertensive effect. SFH also induced a concentration-dependent
vasodilatation of mesenteric resistance arteries contracted with phenylephrine, which was more potent
in arteries from DOCA mice. Removal of the endothelium or pretreatment with L-NAME or catalase re-
duced the vasodilator response for SFH. The nitrite production induced by SFH was significantly bigger
in mesenteric arteries from DOCA than in SHAM mice. However, the production of H2O2 induced by SFH
was twice higher in DOCA mice.
Conclusion: Altogether, our results point to an antihypertensive effect of SFH due to a reduction in periph-
eral resistance through the production of NO and by a mechanism involving an increased production of
H2O2 in the mesenteric arteries from hypertensive mice. These findings are further evidence to support
the use of Hancornia speciosa by traditional medicine as an antihypertensive drug.
Abstract
Assunto
Apocynaceae, Hipertensão, Anti-hipertensivos, Plantas medicinais
Palavras-chave
Hancornia speciosa Gomes, Hypertension, Antihypertensive drugs, Medicinal plants
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https://www.sciencedirect.com/science/article/pii/S0944711315003839